Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 3/20 | 0.46 |
| ▸ | F2 | P00734 | 2/20 | 0.46 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.46 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.46 |
| ▸ | PLG | P00747 | 1/20 | 0.46 |
| ▸ | C1S | P09871 | 1/20 | 0.46 |
| ▸ | ITGB3 | P05106 | 11/20 | 0.44 |
| ▸ | ITGA2B | P08514 | 11/20 | 0.44 |
| ▸ | WDR5 | P61964 | 1/20 | 0.41 |
| ▸ | NQO2 | P16083 | 1/20 | 0.40 |
| ▸ | F10 | P00742 | 3/20 | 0.40 |
| ▸ | TMPRSS15 | P98073 | 1/20 | 0.39 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8410938 | 0.85 | F2 (0.41) | PRSS1F2PRSS2PRSS3PLG | |
| SCHEMBL8407975 | 0.77 | ITGB3 (0.43) | PRSS1F2PRSS2PRSS3PLG | |
| SCHEMBL10805196 | 0.77 | HDAC3 (0.53) | — | |
| SCHEMBL8407626 | 0.74 | CYP2C19 (0.47) | PRSS1F2PRSS2PRSS3PLG | |
| SCHEMBL289158 | 0.72 | ITGB3 (0.74) | PRSS1F2PRSS2PRSS3PLG | |
| SCHEMBL8409513 | 0.72 | KMT2A (0.48) | PRSS1F2PRSS2PRSS3PLG | |
| SCHEMBL8186382 | 0.71 | ITGB3 (0.72) | PRSS1F2PRSS2PRSS3PLG | |
| SCHEMBL8410366 | 0.71 | PRSS1 (0.65) | PRSS1F2PLGITGB3ITGA2B | |
| SCHEMBL8410910 | 0.70 | HDAC1 (0.49) | PRSS1F2PRSS2PRSS3PLG | |
| SCHEMBL7118598 | 0.70 | ITGB3 (0.74) | PRSS1F2PRSS2PRSS3PLG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5922763-A | ANTICOAGULANT; CARDIOVASCULAR DISORDERS | DR. KARL THOMAE GMBH (DE) | 1999-07-13 | — | — | US | disclosed |
| US-5736559-A | CARDIOVASCULAR DISORDERS; RESPIRATORY SYSTEM DISORDERS | KARL THOMAE GMBH (DE) | 1998-04-07 | — | — | US | disclosed |
| US-5597825-A | AGGREGATION INHIBITORS | DR. KARL THOMAE GMBH (DE) | 1997-01-28 | — | — | US | disclosed |
| EP-0496378-A1 | Biphenylderivatives, drugs containing these compounds and processes for their preparation | Dr. Karl Thomae GmbH (DE) | 1992-07-29 | — | — | EP | disclosed |