Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 11/20 | 0.43 |
| ▸ | ITGA2B | P08514 | 11/20 | 0.43 |
| ▸ | WDR5 | P61964 | 1/20 | 0.42 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | PLG | P00747 | 1/20 | 0.40 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.40 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.40 |
| ▸ | C1S | P09871 | 1/20 | 0.40 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.40 |
| ▸ | NQO2 | P16083 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8714699 | 0.85 | TMPRSS15 (0.39) | ITGB3ITGA2BWDR5F2PRSS1 | |
| SCHEMBL8409183 | 0.77 | PRSS1 (0.46) | ITGB3ITGA2BWDR5F2PLG | |
| SCHEMBL6688879 | 0.76 | HDAC3 (0.47) | — | |
| SCHEMBL11368813 | 0.75 | HDAC3 (0.50) | — | |
| SCHEMBL8410910 | 0.74 | HDAC1 (0.49) | ITGB3ITGA2BWDR5F2PLG | |
| SCHEMBL2212818 | 0.74 | HSD17B10 (0.54) | — | |
| SCHEMBL8407255 | 0.73 | PRSS1 (0.68) | ITGB3ITGA2BF2PLGPRSS1 | |
| SCHEMBL8407224 | 0.72 | ALDH1A1 (0.51) | ITGB3ITGA2BWDR5NQO2 | |
| SCHEMBL8410366 | 0.71 | PRSS1 (0.65) | ITGB3ITGA2BF2PLGPRSS1 | |
| SCHEMBL11374320 | 0.71 | CYP1A1 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5922763-A | ANTICOAGULANT; CARDIOVASCULAR DISORDERS | DR. KARL THOMAE GMBH (DE) | 1999-07-13 | — | — | US | disclosed |
| US-5736559-A | CARDIOVASCULAR DISORDERS; RESPIRATORY SYSTEM DISORDERS | KARL THOMAE GMBH (DE) | 1998-04-07 | — | — | US | disclosed |
| US-5597825-A | AGGREGATION INHIBITORS | DR. KARL THOMAE GMBH (DE) | 1997-01-28 | — | — | US | disclosed |
| EP-0496378-B1 | Biphenylderivatives, drugs containing these compounds and processes for their preparation | THOMAE GMBH DR K (DE) | 1995-09-20 | — | — | EP | disclosed |
| EP-0496378-A1 | Biphenylderivatives, drugs containing these compounds and processes for their preparation | Dr. Karl Thomae GmbH (DE) | 1992-07-29 | — | — | EP | disclosed |