SCHEMBL8409198

SCHEMBL8409198

CC1(C)C(C=C(Cl)Cl)C1C(=O)Cl

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPGD P15428 1/20 0.47
LMNA P02545 6/20 0.44
KMT2A Q03164 5/20 0.44
MEN1 O00255 4/20 0.44
HTT P42858 4/20 0.44
ALDH1A1 P00352 3/20 0.44
MAPT P10636 2/20 0.44
NPSR1 Q6W5P4 2/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
TSHR P16473 4/20 0.43
POLB P06746 1/20 0.43
RAB9A P51151 1/20 0.43
ATM Q13315 2/20 0.41
TDP1 Q9NUW8 3/20 0.38
ADRA2A P08913 1/20 0.38
CNR1 P21554 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
GAA P10253 1/20 0.34
CYP1A2 P05177 1/20 0.30
CYP2C19 P33261 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7102387 1.00 HPGD (0.47) HPGDLMNAKMT2AMEN1HTT
SCHEMBL7102385 1.00 HPGD (0.47) HPGDLMNAKMT2AMEN1HTT
SCHEMBL8409202 1.00 HPGD (0.47) HPGDLMNAKMT2AMEN1HTT
SCHEMBL8407543 1.00 HPGD (0.47) HPGDLMNAKMT2AMEN1HTT
SCHEMBL9021196 1.00 HPGD (0.47) HPGDLMNAKMT2AMEN1HTT
SCHEMBL3885618 0.86 LMNA (0.42) HPGDLMNAKMT2AMEN1HTT
SCHEMBL3885619 0.86 LMNA (0.42) HPGDLMNAKMT2AMEN1HTT
SCHEMBL8409028 0.86 LMNA (0.55) HPGDLMNAKMT2AMEN1HTT
SCHEMBL3885617 0.86 LMNA (0.42) HPGDLMNAKMT2AMEN1HTT
SCHEMBL16606352 0.86 LMNA (0.42) HPGDLMNAKMT2AMEN1HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 211 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115093347-A Hapten for detecting cypermethrin content and application thereof 云南省烟草质量监督检测站 2022-09-23 CN claimed
US-10647655-B2 Method for the synthesis of permethrin BIOPHORE INDIA PHARMACEUTICALS PVT. LTD. (IN) 2020-05-12 US claimed
EP-3506748-A1 IMPROVED METHOD FOR THE SYNTHESIS OF PERMETHRIN Biophore India Pharmaceuticals Pvt. Ltd. (IN) 2019-07-10 EP claimed
US-20190194118-A1 IMPROVED METHOD FOR THE SYNTHESIS OF PERMETHRIN BIOPHORE INDIA PHARMACEUTICALS PVT. LTD. (IN) 2019-06-27 US claimed
JP-2514893-B2 1996-07-10 JP claimed
EP-0500572-B1 PREPARATION OF MIXTURES OF CYPERMETHRIN OR CYFLUTHRIN ISOMERS ENRICHED IN MORE ACTIVE SPECIES FMC CORP (US) 1996-02-21 EP claimed
EP-0569461-B1 NOVEL PYRETHROID COMPOSITION FMC CORP (US) 1996-01-24 EP claimed
EP-0569461-A1 NOVEL PYRETHROID COMPOSITION. FMC CORP (US) 1993-11-18 EP claimed
EP-0569461-A4 NOVEL PYRETHROID COMPOSITION. FMC CORP (US) 1993-09-07 EP claimed
US-5164411-A Mixture of cypermethrin isomers FMC CORPORATION (US) 1992-11-17 US claimed
US-4546189-A Preparation of cyano(6-(substituted phenoxy)-2-pyridinyl)methyl esters of 3-(2,2-dihaloethenyl)-2,2-dimethylcyclopropane carboxylic acids THE DOW CHEMICAL COMPANY (US) 1985-10-08 US claimed
EP-0039173-B1 PREPARATION OF CYANO SUBSTITUTED BENZYL ESTER INSECTICIDES ICI AMERICAS INC. (US) 1984-06-13 EP claimed
US-4382894-A Production of α-cyanobenzyl esters CIBA-GEIGY CORPORATION (US) 1983-05-10 US claimed
EP-0050846-A1 Preparation of cyano (6-(substituted phenoxy)-2-pyridinyl) methyl esters of 3-(2,2-dihaloethenyl)-2,2-dimethyl cyclopropane carboxylic acids THE DOW CHEMICAL COMPANY (US) 1982-05-05 EP claimed
US-4299776-A AN A-CYANO-3-PHENOXYBENZYL ESTER FROM THE ACYL HALIDE, 3-PHENOXYBENZALDEHYDE AND A CYANIDE SALT FMC CORPORATION (US) 1981-11-10 US claimed
EP-0039173-A1 Preparation of cyano substituted benzyl ester insecticides ICI AMERICAS INC. (US) 1981-11-04 EP claimed
US-4280965-A Preparation of cyano substituted benzyl esters ICI AMERICAS INC. (US) 1981-07-28 US claimed
US-4234507-A Process for preparing cyanohydrin esters STAUFFER CHEMICAL COMPANY (US) 1980-11-18 US claimed
US-4211727-A CADMIUM BOROHYDRIDE COMPLEX AS REDUCING AGENT SHELL OIL COMPANY (US) 1980-07-08 US claimed
EP-0003242-A1 Process for the preparation of alpha-cyanobenzyl esters SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) 1979-08-08 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10647655-B2 Method for the synthesis of permethrin NUP188, CYP2E1, AQP4 HPGD 885/4885LMNA 2817/4885KMT2A 2522/4885
US-20190194118-A1 IMPROVED METHOD FOR THE SYNTHESIS OF PERMETHRIN CYP51A1, CYP4F3, CYP4F2 HPGD 992/4885LMNA 4054/4885KMT2A 3025/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.