Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 5/20 | 0.47 |
| ▸ | HTR1D | P28221 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | HTR2C | P28335 | 4/20 | 0.42 |
| ▸ | HTR2B | P41595 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | HTR1B | P28222 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12244348 | 0.82 | TP53 (0.50) | HTR2AHTR1DTP53MAPTLMNA | |
| SCHEMBL31567584 | 0.82 | TP53 (0.50) | HTR2AHTR1DTP53MAPTLMNA | |
| SCHEMBL21871531 | 0.82 | LMNA (0.49) | HTR2AHTR1DTP53MAPTLMNA | |
| SCHEMBL20556003 | 0.82 | LMNA (0.49) | HTR2AHTR1DTP53MAPTLMNA | |
| SCHEMBL1120490 | 0.79 | HTR2A (0.67) | HTR2AHTR1DTP53MAPTLMNA | |
| SCHEMBL20970887 | 0.77 | TP53 (0.46) | HTR2AHTR1DTP53MAPTLMNA | |
| SCHEMBL6713999 | 0.77 | TP53 (0.46) | HTR2AHTR1DTP53MAPTLMNA | |
| SCHEMBL4406284 | 0.76 | HTR2A (0.50) | HTR2AHTR1DTP53MAPTHTR2C | |
| SCHEMBL16675479 | 0.75 | TP53 (0.45) | HTR2AHTR1DTP53MAPTLMNA | |
| SCHEMBL9211145 | 0.74 | HTR2B (0.50) | HTR2AHTR1DMAPTSMN1; SMN2HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5869691-A | TETRAHYDRO-BETA-CARBOLINE RELATED COMPOUNDS WHICH ARE USEFUL INTERMEDIATES AND HAVE BENEFICIAL CENTRAL NERVOUS SYSTEM ACTIVITY. | ELI LILLY AND COMPANY (US) | 1999-02-09 | — | — | US | disclosed |
| US-5861410-A | TREATING A FUNCTIONAL BOWEL DISORDER | ELI LILLY AND COMPANY (US) | 1999-01-19 | — | — | US | disclosed |
| US-5861408-A | SEROTONIN RECEPTOR ANTAGONISTS, INHIBITORS OF SEROTONIN-INDUCED COLON CONCTRACTIONS, FOR TREATING GASTROINTESTINAL DISORDERS | ELI LILLY AND COMPANY (US) | 1999-01-19 | — | — | US | disclosed |
| US-5861409-A | Tetrahydro-beta-carbolines | ELI LILLY AND COMPANY (US) | 1999-01-19 | — | — | US | disclosed |
| US-5736544-A | ADMINISTERING TO TREAT MIGRAINE HEADACHES IN MAMMALS | ELI LILLY AND COMPANY (US) | 1998-04-07 | — | — | US | disclosed |
| US-5705519-A | ADMINISTERING A SUBSTITUTED INDOLE TO A MAMMAL | ELI LILLY AND COMPANY (US) | 1998-01-06 | — | — | US | disclosed |
| US-5688807-A | ANTIDEPRESSANTS, ANXIETY, UROGENITAL DISORDERS, HYPOTENSIVES, CARDIOVASCULAR DISORDERS | ELI LILLY AND COMPANY (US) | 1997-11-18 | — | — | US | disclosed |
| US-5663178-A | 5-HT2 RECEPTOR ANTABONISTS | ELI LILLY AND COMPANY (US) | 1997-09-02 | — | — | US | disclosed |
| US-5643916-A | 5-HT(2B) RECEPTOR MODULATORS | ELI LILLY AND COMPANY (US) | 1997-07-01 | — | — | US | disclosed |
| US-5629317-A | SEROTONIN ANTAGONIST | ELI LILLY AND COMPANY (US) | 1997-05-13 | — | — | US | disclosed |
| CN-1148340-A | Treatment of 5HTZBMethods of receptor-related disorders | LILLY CO ELI (US) | 1997-04-23 | — | — | CN | disclosed |