Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2B | P41595 | 3/20 | 0.50 |
| ▸ | HTR2A | P28223 | 2/20 | 0.50 |
| ▸ | HTR2C | P28335 | 2/20 | 0.50 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | THRA | P10827 | 6/20 | 0.41 |
| ▸ | THRB | P10828 | 6/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
| ▸ | HTR1B | P28222 | 2/20 | 0.40 |
| ▸ | HTR1D | P28221 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9204071 | 0.89 | HTR2B (0.60) | HTR2BHTR2AHTR2CHTR1ATRPM8 | |
| SCHEMBL9213440 | 0.83 | HTR2A (0.45) | HTR2BHTR2AHTR2CTRPM8MAPT | |
| SCHEMBL30888858 | 0.82 | HTR2B (0.71) | HTR2BHTR2AHTR2CHTR1ATRPM8 | |
| SCHEMBL9210783 | 0.80 | LMNA (0.48) | HTR2BHTR2AHTR2CHTR1ATRPM8 | |
| SCHEMBL9203861 | 0.80 | HTR2B (0.50) | HTR2BHTR2AHTR2CHTR1ATRPM8 | |
| SCHEMBL25553512 | 0.79 | MAPT (0.48) | HTR2BHTR2AHTR2CHTR1ATRPM8 | |
| SCHEMBL9206198 | 0.78 | THRA (0.44) | HTR2BHTR2AHTR2CHTR1ATRPM8 | |
| SCHEMBL8869778 | 0.75 | SCN9A (0.45) | MAPTTHRATHRBMTNR1AMTNR1B | |
| SCHEMBL8409476 | 0.74 | HTR2A (0.47) | HTR2BHTR2AHTR2CHTR1AMAPT | |
| SCHEMBL4406284 | 0.73 | HTR2A (0.50) | HTR2BHTR2AHTR2CHTR1AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0674619-A1 | TRYPTAMINE ANALOGUES AS 5-HT 1?-LIKE AGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-10-04 | — | — | EP | claimed |
| WO-1994014770-A1 | TRYPTAMINE ANALOGUES AS 5-HT1-LIKE AGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-07-07 | — | — | WO | claimed |
| EP-0674619-A1 | TRYPTAMINE ANALOGUES AS 5-HT 1?-LIKE AGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-10-04 | — | — | EP | disclosed |
| WO-1994014770-A1 | TRYPTAMINE ANALOGUES AS 5-HT1-LIKE AGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-07-07 | — | — | WO | disclosed |