Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 9/20 | 0.61 |
| ▸ | MTNR1B | P49286 | 9/20 | 0.61 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8409866 | 0.96 | MTNR1A (0.56) | MTNR1AMTNR1BMAPTCYP1A2CYP2C9 | |
| SCHEMBL8410102 | 0.88 | MTNR1A (0.59) | MTNR1AMTNR1BMAPTALDH1A1NPSR1 | |
| SCHEMBL8409835 | 0.88 | MTNR1A (0.61) | MTNR1AMTNR1BMAPTCYP1A2CYP2C9 | |
| SCHEMBL8410162 | 0.84 | MTNR1A (0.44) | MTNR1AMTNR1BMAPTCYP1A2CYP2C9 | |
| SCHEMBL8409648 | 0.84 | MTNR1A (0.59) | MTNR1AMTNR1BMAPTALDH1A1NPSR1 | |
| SCHEMBL8407080 | 0.82 | MTNR1A (0.61) | MTNR1AMTNR1BMAPTCYP1A2CYP2C9 | |
| SCHEMBL8409684 | 0.80 | CYP1A2 (0.57) | MAPTCYP1A2ALOX15ALDH1A1NPSR1 | |
| SCHEMBL8406956 | 0.78 | MTNR1A (0.56) | MTNR1AMTNR1BMAPTCYP1A2CYP2C9 | |
| SCHEMBL81120 | 0.76 | MTNR1A (1.00) | MTNR1AMTNR1BMAPTCYP1A2CYP2C9 | |
| SCHEMBL8406932 | 0.74 | ADRA1A (0.60) | MAPTALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0737670-B1 | Tricyclic amides, processes for their preparation, and pharmaceutical compositions containing them | ADIR (FR) | 1999-07-21 | — | — | EP | disclosed |
| US-5849781-A | Tricyclic amides | ADIR ET COMPAGNIE (FR) | 1998-12-15 | — | — | US | disclosed |
| US-5712312-A | MELATONINERGIC RECEPTOR LIGANDS, TREATMENT OF SLEEP DISORDERS | ADIR ET COMPAGNIE (FR) | 1998-01-27 | — | — | US | disclosed |
| EP-0737670-A1 | Tricyclic amides, processes for their preparation, and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1996-10-16 | — | — | EP | disclosed |