Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 7/20 | 0.59 |
| ▸ | MTNR1B | P49286 | 7/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8410102 | 0.95 | MTNR1A (0.59) | MTNR1AMTNR1BALDH1A1MAPTNPSR1 | |
| SCHEMBL8409643 | 0.84 | MTNR1A (0.61) | MTNR1AMTNR1BALDH1A1MAPTNPSR1 | |
| SCHEMBL8409835 | 0.83 | MTNR1A (0.61) | MTNR1AMTNR1BMAPT | |
| SCHEMBL8409866 | 0.82 | MTNR1A (0.56) | MTNR1AMTNR1BALDH1A1MAPTNPSR1 | |
| SCHEMBL8410162 | 0.82 | MTNR1A (0.44) | MTNR1AMTNR1BALDH1A1MAPTNPSR1 | |
| SCHEMBL8408962 | 0.81 | MTNR1A (0.59) | MTNR1AMTNR1BMAPT | |
| SCHEMBL11496541 | 0.81 | MTNR1A (0.72) | MTNR1AMTNR1BMAPTCA1CA2 | |
| SCHEMBL8409903 | 0.76 | ADRA1A (0.60) | ALDH1A1MAPTNPSR1 | |
| SCHEMBL3919777 | 0.75 | MTNR1A (1.00) | MTNR1AMTNR1BMAPTCA1CA2 | |
| SCHEMBL8409684 | 0.74 | CYP1A2 (0.57) | ALDH1A1MAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0737670-B1 | Tricyclic amides, processes for their preparation, and pharmaceutical compositions containing them | ADIR (FR) | 1999-07-21 | — | — | EP | disclosed |
| US-5849781-A | Tricyclic amides | ADIR ET COMPAGNIE (FR) | 1998-12-15 | — | — | US | disclosed |
| US-5712312-A | MELATONINERGIC RECEPTOR LIGANDS, TREATMENT OF SLEEP DISORDERS | ADIR ET COMPAGNIE (FR) | 1998-01-27 | — | — | US | disclosed |
| EP-0737670-A1 | Tricyclic amides, processes for their preparation, and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1996-10-16 | — | — | EP | disclosed |