SCHEMBL8409673

SCHEMBL8409673

COC(=O)c1ccc(C(C)Oc2ccccc2CCc2ccccc2)cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MGLL Q99685 1/20 0.47
CA1 P00915 1/20 0.45
CA2 P00918 1/20 0.45
CYP1A2 P05177 2/20 0.44
CYP3A4 P08684 2/20 0.44
CYP2C9 P11712 2/20 0.44
CYP2C19 P33261 2/20 0.44
ALDH1A1 P00352 1/20 0.44
TP53 P04637 1/20 0.44
HPGD P15428 1/20 0.44
ALOX15 P16050 1/20 0.44
ALOX12 P18054 1/20 0.44
CKS1B P61024 1/20 0.44
SKP2 Q13309 1/20 0.44
HIF1A Q16665 1/20 0.44
HSD17B10 Q99714 1/20 0.44
LMNA P02545 1/20 0.44
MAPT P10636 1/20 0.44
NPC1 O15118 1/20 0.43
RAB9A P51151 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8408172 0.89 PTGER4 (0.51) NPC1RAB9AABCB1KMT2AFFAR1
SCHEMBL8409582 0.80 POLB (0.44) MGLLCA1CA2CYP1A2CYP3A4
SCHEMBL8162236 0.80 ALDH1A1 (0.60) MGLLCA1CA2CYP1A2CYP3A4
SCHEMBL10397850 0.79 ALDH1A1 (0.56) CYP1A2CYP3A4CYP2C9CYP2C19ALDH1A1
SCHEMBL8406671 0.79 HTR1A (0.66) CYP1A2CYP3A4CYP2C9CYP2C19ALDH1A1
SCHEMBL8409671 0.79 ABCB1 (0.51) MGLLCA1CA2CYP1A2CYP3A4
SCHEMBL14967228 0.78 TSHR (0.47) CA1CA2ALDH1A1LMNAMAPT
SCHEMBL14967136 0.78 L3MBTL1 (0.55) CA1CA2ALDH1A1HPGDLMNA
SCHEMBL7776446 0.77 MAPT (0.51) MGLLCA1CA2CYP1A2CYP3A4
SCHEMBL1928912 0.77 TSHR (0.67) MGLLCA1CA2CYP1A2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0778821-B1 ORTHO-SUBSTITUTED AROMATIC ETHER COMPOUNDS AND THEIR USE IN PHARMACEUTICAL COMPOSITIONS FOR PAIN RELIEF ZENECA LTD (GB) 1999-10-20 EP disclosed
US-5965741-A ANTIINFLAMMATORY, ANTIPYRETIC AND ANTIDIARRHOEAL PROPERTIES ZENECA LIMITED (GB) 1999-10-12 US disclosed
EP-0778821-A1 ORTHO-SUBSTITUTED AROMATIC ETHER COMPOUNDS AND THEIR USE IN PHARMACEUTICAL COMPOSITIONS FOR PAIN RELIEF ZENECA LIMITED (GB) 1997-06-18 EP disclosed