SCHEMBL8409869

SCHEMBL8409869

O=c1cc(Nc2ccccc2)[nH]n1-c1c(Cl)c(Cl)c(Cl)c(Cl)c1Cl

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GSK3B P49841 3/20 0.39
CHEK1 O14757 1/20 0.39
AURKA O14965 1/20 0.39
PIM1 P11309 1/20 0.39
MAPT P10636 5/20 0.39
ALDH1A1 P00352 4/20 0.39
KDM4E B2RXH2 3/20 0.39
HPGD P15428 2/20 0.39
CDC25B P30305 2/20 0.39
APAF1 O14727 1/20 0.39
THRB P10828 1/20 0.39
CASP3 P42574 1/20 0.39
RECQL P46063 1/20 0.39
GALK1 P51570 1/20 0.39
UBE2I P63279 1/20 0.39
SMAD3 P84022 1/20 0.39
SENP8 Q96LD8 1/20 0.39
SENP7 Q9BQF6 1/20 0.39
SENP6 Q9GZR1 1/20 0.39
SAE1 Q9UBE0 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4579460 0.85 MEN1 (0.38) GSK3BCHEK1AURKAPIM1MAPT
SCHEMBL7039254 0.82 MAPT (0.50) GSK3BCHEK1AURKAPIM1MAPT
SCHEMBL8909512 0.80 ALKBH5 (0.54) GSK3BMAPTALDH1A1KDM4EHPGD
SCHEMBL8517309 0.80 ALDH1A1 (0.41) GSK3BCHEK1AURKAPIM1MAPT
SCHEMBL9763528 0.77 ALKBH5 (0.50) MAPTALDH1A1KDM4EHPGDTHRB
SCHEMBL11211599 0.72 SNCA (0.46) MAPTALDH1A1KDM4EPOLBMEN1
SCHEMBL11841834 0.71 GAA (0.40) GSK3BMAPTALDH1A1KDM4ECDC25B
SCHEMBL11811879 0.69 CA12 (0.45) MAPTALDH1A1APAF1CASP3GALK1
SCHEMBL11283689 0.68 MERTK (0.39) GSK3BMAPTALDH1A1MEN1KMT2A
SCHEMBL10607174 0.67 GSK3A (0.44) GSK3BMAPTALDH1A1KDM4EPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0742200-B1 Manufacturing method of sulphides KONISHIROKU PHOTO IND (JP) 1999-07-21 EP claimed
US-5763618-A OXIDIZING A THIOL, REACTING THE RESULTING DISULFIDE WITH A COUPLER IN THE PRESENCE OF A BASE AND SECOND OXIDIZING AGENT KONICA CORPORATION (JP) 1998-06-09 US claimed
EP-0742200-A1 Manufacturing method of sulphides KONICA CORPORATION (JP) 1996-11-13 EP claimed
JP-9124589-A None JP disclosed
EP-0742200-B1 Manufacturing method of sulphides KONISHIROKU PHOTO IND (JP) 1999-07-21 EP disclosed
US-5763618-A OXIDIZING A THIOL, REACTING THE RESULTING DISULFIDE WITH A COUPLER IN THE PRESENCE OF A BASE AND SECOND OXIDIZING AGENT KONICA CORPORATION (JP) 1998-06-09 US disclosed
JP-H09124589-A PRODUCTION OF SULFIDES KONICA CORP 1997-05-13 JP disclosed
EP-0742200-A1 Manufacturing method of sulphides KONICA CORPORATION (JP) 1996-11-13 EP disclosed
US-5447831-A Associated with green sensitive layer, prints with improved color balance EASTMAN KODAK COMPANY (US) 1995-09-05 US disclosed
EP-0649056-A2 Photographic element and process employing hue correction couplers EASTMAN KODAK COMPANY (US) 1995-04-19 EP disclosed