Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 7/20 | 0.64 |
| ▸ | PGR | P06401 | 1/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.64 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL359321 | 0.83 | ALDH1A1 (0.60) | HTTALDH1A1MAPTTHRBMEN1 | |
| SCHEMBL27630726 | 0.82 | AR (0.69) | ARPGRCYP3A4ALDH1A1MAPT | |
| SCHEMBL8409262 | 0.81 | AR (0.67) | ARPGRCYP3A4HTTALDH1A1 | |
| SCHEMBL8407369 | 0.81 | AR (0.71) | ARPGRCYP3A4HTTALDH1A1 | |
| SCHEMBL8407245 | 0.81 | AR (0.67) | ARPGRCYP3A4HTTMEN1 | |
| SCHEMBL7557518 | 0.80 | HTT (0.45) | ARPGRCYP3A4HTTALDH1A1 | |
| SCHEMBL11512455 | 0.80 | ALDH1A1 (0.62) | ARCYP3A4HTTALDH1A1MAPT | |
| SCHEMBL6384031 | 0.80 | ALDH1A1 (0.57) | HTTALDH1A1MAPTTHRBMEN1 | |
| SCHEMBL14166115 | 0.79 | ALDH1A1 (0.49) | CYP3A4HTTALDH1A1MAPTTHRB | |
| Hydroxyflutamide SCHEMBL3079778 | 0.78 | AR (1.00) | ARPGRCYP3A4HTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5994362-A | ADMINISTERING FINASTERIDE AND CASODEX | MERCK & CO., INC. (US) | 1999-11-30 | — | — | US | disclosed |
| EP-0514056-A2 | Use of estrogens or antiandrogens for reversal of male sexual phenotype in poultry | MERCK & CO. INC. (US) | 1992-11-19 | — | — | EP | disclosed |
| WO-1992016233-A1 | PHARMACEUTICAL COMBINATION FOR THE TREATMENT OF PROSTATIC CANCER CONTAINING A 5 ALPHA REDUCTASE INHIBITOR AND AN ANTIANDROGEN | MERCK & CO., INC. (US) | 1992-10-01 | — | — | WO | disclosed |