Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP3 | P08254 | 7/20 | 0.64 |
| ▸ | MMP2 | P08253 | 7/20 | 0.64 |
| ▸ | MMP1 | P03956 | 1/20 | 0.63 |
| ▸ | MMP9 | P14780 | 1/20 | 0.63 |
| ▸ | MMP13 | P45452 | 1/20 | 0.63 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.63 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.50 |
| ▸ | HRH2 | P25021 | 3/20 | 0.50 |
| ▸ | HRH1 | P35367 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8410478 | 0.96 | MMP3 (0.71) | MMP3MMP2MMP1MMP9MMP13 | |
| SCHEMBL6328940 | 0.95 | MAPT (0.58) | MMP3MMP2MMP1MMP9MMP13 | |
| SCHEMBL1285443 | 0.94 | HDAC1 (0.71) | MMP3MMP2MMP1MMP9MMP13 | |
| SCHEMBL4832930 | 0.91 | MMP3 (0.63) | MMP3MMP2MMP1MMP9MMP13 | |
| SCHEMBL13087979 | 0.88 | MMP2 (0.62) | MMP3MMP2MMP1MMP9MMP13 | |
| SCHEMBL1285386 | 0.86 | MMP2 (0.61) | MMP3MMP2MMP1MMP9MMP13 | |
| SCHEMBL1285929 | 0.86 | MMP2 (0.61) | MMP3MMP2MMP1MMP9MMP13 | |
| SCHEMBL1715131 | 0.83 | HDAC1 (0.57) | MMP3MMP2MMP1MMP9MMP13 | |
| SCHEMBL1285747 | 0.83 | MMP2 (0.85) | MMP3MMP2MMP1MMP9MMP13 | |
| SCHEMBL7364711 | 0.83 | HDAC3 (0.65) | MMP3HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5922763-A | ANTICOAGULANT; CARDIOVASCULAR DISORDERS | DR. KARL THOMAE GMBH (DE) | 1999-07-13 | — | — | US | disclosed |
| US-5736559-A | CARDIOVASCULAR DISORDERS; RESPIRATORY SYSTEM DISORDERS | KARL THOMAE GMBH (DE) | 1998-04-07 | — | — | US | disclosed |
| US-5597825-A | AGGREGATION INHIBITORS | DR. KARL THOMAE GMBH (DE) | 1997-01-28 | — | — | US | disclosed |
| EP-0496378-B1 | Biphenylderivatives, drugs containing these compounds and processes for their preparation | THOMAE GMBH DR K (DE) | 1995-09-20 | — | — | EP | disclosed |
| EP-0496378-A1 | Biphenylderivatives, drugs containing these compounds and processes for their preparation | Dr. Karl Thomae GmbH (DE) | 1992-07-29 | — | — | EP | disclosed |