Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | AGTR1 | P30556 | 10/20 | 0.32 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 3/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.30 |
| ▸ | FSHR | P23945 | 1/20 | 0.30 |
| ▸ | ACE | P12821 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.30 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.30 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.30 |
| ▸ | GP6 | Q9HCN6 | 1/20 | 0.30 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL839507 | 1.00 | MEN1 (0.39) | MEN1KMT2AAGTR1AGTR2GAA | |
| SCHEMBL839172 | 0.91 | AGTR1 (0.37) | MEN1KMT2AAGTR1AGTR2GAA | |
| SCHEMBL840633 | 0.89 | AGTR1 (0.37) | AGTR1AGTR2ABCB11GP6LTB4R2 | |
| SCHEMBL840776 | 0.89 | AGTR1 (0.37) | AGTR1AGTR2ABCB11GP6LTB4R2 | |
| SCHEMBL839095 | 0.89 | MEN1 (0.41) | MEN1KMT2AAGTR1GAAACE | |
| SCHEMBL841114 | 0.86 | MEN1 (0.42) | MEN1KMT2AGAALMNAKDM4E | |
| SCHEMBL841047 | 0.86 | MMP8 (0.41) | MEN1KMT2A | |
| SCHEMBL839515 | 0.83 | MMP8 (0.41) | MEN1KMT2A | |
| SCHEMBL841272 | 0.82 | AGTR1 (0.40) | AGTR1AGTR2FSHRLTB4R2 | |
| SCHEMBL839257 | 0.81 | AGTR1 (0.37) | AGTR1AGTR2FSHRLTB4R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143298-B2 | Dual-acting antihypertensive agents | THERAVANCE, INC. (US) | 2012-03-27 | — | — | US | disclosed |