Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | MME | P08473 | 3/20 | 0.35 |
| ▸ | ACE | P12821 | 3/20 | 0.35 |
| ▸ | CPA1 | P15085 | 2/20 | 0.35 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 4/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | REN | P00797 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL839095 | 0.91 | MEN1 (0.41) | MEN1KMT2AGAAMMEACE | |
| SCHEMBL839515 | 0.89 | MMP8 (0.41) | MEN1KMT2AMME | |
| SCHEMBL839303 | 0.89 | LTB4R2 (0.37) | MMEACECPA1ACE2REN | |
| SCHEMBL839302 | 0.89 | LTB4R2 (0.37) | MMEACECPA1ACE2REN | |
| SCHEMBL839507 | 0.86 | MEN1 (0.39) | MEN1KMT2AGAAACETSHR | |
| SCHEMBL841065 | 0.86 | MEN1 (0.39) | MEN1KMT2AGAAACETSHR | |
| SCHEMBL839172 | 0.84 | AGTR1 (0.37) | MEN1KMT2AGAAMME | |
| SCHEMBL841047 | 0.82 | MMP8 (0.41) | MEN1KMT2A | |
| SCHEMBL840147 | 0.80 | MME (0.42) | MEN1KMT2AMMEACEALDH1A1 | |
| SCHEMBL2973817 | 0.80 | MME (0.40) | MMEACECPA1ACE2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143298-B2 | Dual-acting antihypertensive agents | THERAVANCE, INC. (US) | 2012-03-27 | — | — | US | disclosed |