Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | APEX1 | P27695 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | NOS1 | P29475 | 2/20 | 0.31 |
| ▸ | NOS2 | P35228 | 2/20 | 0.31 |
| ▸ | NOS3 | P29474 | 1/20 | 0.31 |
| ▸ | ARG1 | P05089 | 1/20 | 0.31 |
| ▸ | ARG2 | P78540 | 1/20 | 0.31 |
| ▸ | BHMT | Q93088 | 1/20 | 0.30 |
| ▸ | BHMT2 | Q9H2M3 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17632961 | 0.86 | DGKA (0.36) | CYP1A2MAPTAPEX1TDP1NOS1 | |
| SCHEMBL5014586 | 0.84 | TSHR (0.42) | TSHRPOLBGAAMAPTTDP1 | |
| SCHEMBL5014587 | 0.81 | TDP1 (0.52) | TSHRPOLBGAAMAPTTDP1 | |
| SCHEMBL22110077 | 0.81 | TSHR (0.43) | TSHRCYP1A2APEX1TDP1NOS1 | |
| SCHEMBL14418405 | 0.78 | LPAR1 (0.35) | MAPT | |
| SCHEMBL18133674 | 0.77 | TSHR (0.37) | TSHRPOLBGAAMAPTTDP1 | |
| SCHEMBL8411503 | 0.77 | HDAC3 (0.38) | CYP1A2GAAAPEX1NOS1NOS2 | |
| SCHEMBL15082197 | 0.77 | HDAC3 (0.38) | CYP1A2GAAAPEX1NOS1NOS2 | |
| SCHEMBL14996174 | 0.76 | TSHR (0.42) | TSHRPOLBGAAMAPTTDP1 | |
| SCHEMBL15927968 | 0.76 | LMNA (0.54) | TSHRCYP1A2APEX1TDP1NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0932598-A1 | ASPARTATE ESTER INHIBITORS OF INTERLEUKIN-1$g(b) CONVERTING ENZYME | WARNER-LAMBERT COMPANY (US) | 1999-08-04 | — | — | EP | disclosed |
| WO-1998016502-A1 | ASPARTATE ESTER INHIBITORS OF INTERLEUKIN-1β CONVERTING ENZYME | WARNER-LAMBERT COMPANY (US) | 1998-04-23 | — | — | WO | disclosed |