Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 10/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 8/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 6/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 6/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.49 |
| ▸ | HDAC9 | Q9UKV0 | 6/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.49 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.49 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.49 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.46 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.45 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.45 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.45 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8411708 | 0.89 | HDAC1 (0.60) | HDAC1HDAC6HDAC3HDAC4HDAC2 | |
| SCHEMBL7564725 | 0.85 | HDAC1 (0.49) | HDAC1HDAC6HDAC3HDAC4HDAC2 | |
| SCHEMBL7566327 | 0.84 | TMEM97 (0.62) | HDAC1HDAC6HDAC3HDAC4HDAC2 | |
| SCHEMBL26112451 | 0.79 | KDM4C (0.57) | KDM4EALDH1A1HPGDGAACYP1A2 | |
| SCHEMBL30572035 | 0.75 | STAMBP (0.51) | HDAC1HDAC6HDAC3HDAC4HDAC2 | |
| SCHEMBL8411680 | 0.75 | HDAC1 (0.47) | HDAC1HDAC6OPRM1TMEM97SIGMAR1 | |
| SCHEMBL1193424 | 0.74 | HDAC1 (0.66) | HDAC1HDAC6HDAC3HDAC4HDAC2 | |
| SCHEMBL7566454 | 0.73 | TMEM97 (0.58) | OPRM1TMEM97SIGMAR1KDM4EALDH1A1 | |
| SCHEMBL27739759 | 0.72 | ALDH1A1 (0.58) | KDM4EALDH1A1HPGDMEN1POLB | |
| SCHEMBL8414466 | 0.72 | AOX1 (0.57) | HDAC1HDAC6KDM4EALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934278-A1 | BIS(ACRIDINECARBOXAMIDE) AND BIS(PHENAZINECARBOXAMIDE) AS ANTITUMOUR AGENTS | XENOVA LIMITED (GB) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998017650-A1 | BIS(ACRIDINECARBOXAMIDE) AND BIS(PHENAZINECARBOXAMIDE) AS ANTITUMOUR AGENTS | XENOVA LIMITED (GB) | 1998-04-30 | — | — | WO | disclosed |