Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | USP5 | P45974 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8412985 | 0.81 | ALDH1A1 (0.44) | ALDH1A1TDP1KMT2AOPRM1OPRD1 | |
| SCHEMBL6133961 | 0.80 | GSK3B (0.48) | ALDH1A1TDP1KMT2AMEN1OPRM1 | |
| SCHEMBL15003979 | 0.80 | HSD17B3 (0.45) | ALDH1A1TDP1KMT2AOPRM1OPRD1 | |
| SCHEMBL9192054 | 0.79 | KMT2A (0.46) | ALDH1A1TDP1KMT2AMEN1OPRM1 | |
| SCHEMBL4285053 | 0.79 | GSK3B (0.50) | ALDH1A1TDP1KMT2AMEN1OPRM1 | |
| SCHEMBL9841175 | 0.79 | ALDH1A1 (0.43) | ALDH1A1TDP1KMT2AMEN1OPRM1 | |
| SCHEMBL232290 | 0.77 | HCAR2 (0.50) | ALDH1A1TDP1KMT2AMEN1OPRM1 | |
| SCHEMBL29365646 | 0.77 | HCAR2 (0.50) | ALDH1A1TDP1KMT2AMEN1OPRM1 | |
| Hydrochloric Acid SCHEMBL9722613 | 0.77 | ALDH1A1 (0.43) | ALDH1A1TDP1KMT2AMEN1OPRM1 | |
| Hydrochloric Acid SCHEMBL7476482 | 0.76 | HCAR2 (0.48) | ALDH1A1TDP1KMT2AMEN1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5994540-A | HYDROXY- AND CHLORO-PYRIDYLPYRIDAZINONE DERIVATIVES | LONZA, LTD. (CH) | 1999-11-30 | — | — | US | disclosed |
| US-5760236-A | CHEMICAL INTERMEDIATES FOR PHARMACEUTICALS | LONZA, LTD. (CH) | 1998-06-02 | — | — | US | disclosed |