Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 3/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.45 |
| ▸ | PLD2 | O14939 | 3/20 | 0.45 |
| ▸ | PLD1 | Q13393 | 3/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.43 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CALCRL | Q16602 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6161025 | 0.79 | CALCRL (0.56) | HSD11B1CHRM1CHRM2CHRM4CHRM5 | |
| SCHEMBL6161030 | 0.79 | CALCRL (0.56) | HSD11B1CHRM1CHRM2CHRM4CHRM5 | |
| SCHEMBL8409763 | 0.75 | OPRM1 (0.40) | OPRM1OPRK1OPRL1 | |
| SCHEMBL7491407 | 0.75 | OPRM1 (0.63) | OPRM1OPRK1OPRL1KDM4EALDH1A1 | |
| SCHEMBL7489071 | 0.71 | OPRM1 (0.65) | OPRM1OPRK1OPRL1KDM4EALDH1A1 | |
| SCHEMBL6164868 | 0.71 | CALCRL (0.60) | HSD11B1CALCRL | |
| SCHEMBL6164873 | 0.71 | CALCRL (0.60) | HSD11B1CALCRL | |
| SCHEMBL8409918 | 0.71 | HSD11B1 (0.45) | OPRM1KDM4EALDH1A1PMP22NPSR1 | |
| Hydrochloric Acid SCHEMBL6165220 | 0.70 | CALCRL (0.59) | HSD11B1CALCRL | |
| Hydrochloric Acid SCHEMBL6162663 | 0.70 | CALCRL (0.59) | HSD11B1CALCRL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5936089-A | PIPERIDINE DERIVATIVES; BONE DISORDERS; OBESITY; AGING; CACHEXIA ASSOCIATED WITH AIDS AND CANCER | PFIZER INC (US) | 1999-08-10 | — | — | US | disclosed |