Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRB | P28702 | 9/20 | 0.40 |
| ▸ | RXRA | P19793 | 9/20 | 0.40 |
| ▸ | RXRG | P48443 | 6/20 | 0.40 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.34 |
| ▸ | S1PR5 | Q9H228 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8414265 | 0.79 | RXRB (0.38) | RXRBRXRARXRGMRGPRX4MCL1 | |
| SCHEMBL8410701 | 0.76 | RXRB (0.40) | RXRBRXRARXRGMRGPRX4MCL1 | |
| SCHEMBL8414037 | 0.70 | RXRA (0.36) | RXRBRXRARXRGMRGPRX4MCL1 | |
| SCHEMBL8811750 | 0.70 | ACHE (0.35) | — | |
| SCHEMBL8809708 | 0.70 | PTGIR (0.39) | RXRBMRGPRX4SMN1; SMN2 | |
| SCHEMBL8413331 | 0.70 | PTGIR (0.39) | RXRBMRGPRX4SMN1; SMN2 | |
| SCHEMBL8414341 | 0.70 | MCL1 (0.35) | RXRBRXRARXRGMRGPRX4MCL1 | |
| SCHEMBL8410980 | 0.69 | RXRA (0.37) | RXRBRXRARXRGMRGPRX4MCL1 | |
| SCHEMBL8414350 | 0.69 | RXRA (0.42) | RXRBRXRARXRGMRGPRX4MCL1 | |
| SCHEMBL8811745 | 0.67 | PTGIR (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5962439-A | CARDIOVASCULAR DISORDER | ONO PHARMACEUTICAL CO., LTD. (JP) | 1999-10-05 | — | — | US | disclosed |
| US-5849919-A | Fused benzeneoxyacetic acid derivatives which have PGI2 receptor anonist activity | ONO PHARMACEUTICAL CO., LTD. (JP) | 1998-12-15 | — | — | US | disclosed |