SCHEMBL8413375

SCHEMBL8413375

COC1=N/C(=C/c2ccc(OC)cc2)C(=O)N(C(C)=O)C1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AKR1B1 P15121 2/20 0.51
RAB9A P51151 3/20 0.50
NPC1 O15118 2/20 0.50
MAPT P10636 7/20 0.49
CYP1A2 P05177 1/20 0.49
CYP3A4 P08684 1/20 0.49
CYP2C9 P11712 1/20 0.49
CYP2C19 P33261 1/20 0.49
ALDH1A1 P00352 6/20 0.48
SMN1; SMN2 Q16637 4/20 0.48
KDM4E B2RXH2 3/20 0.43
LMNA P02545 2/20 0.43
L3MBTL1 Q9Y468 1/20 0.43
MEN1 O00255 1/20 0.42
KMT2A Q03164 1/20 0.42
HTT P42858 1/20 0.42
HPGD P15428 2/20 0.41
PIM1 P11309 2/20 0.41
PIM2 Q9P1W9 1/20 0.41
CDK5 Q00535 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8413379 1.00 AKR1B1 (0.51) AKR1B1RAB9ANPC1MAPTCYP1A2
SCHEMBL8411264 0.73 HRH3 (0.64) AKR1B1RAB9ANPC1ALDH1A1MEN1
SCHEMBL8411774 0.73 PABPC1 (0.54) AKR1B1RAB9ANPC1MAPTCYP1A2
SCHEMBL8573167 0.73 HRH3 (0.64) AKR1B1RAB9ANPC1ALDH1A1MEN1
SCHEMBL8412001 0.73 PABPC1 (0.54) AKR1B1RAB9ANPC1MAPTCYP1A2
SCHEMBL8411263 0.73 HRH3 (0.64) AKR1B1RAB9ANPC1ALDH1A1MEN1
SCHEMBL8411772 0.73 PABPC1 (0.54) AKR1B1RAB9ANPC1MAPTCYP1A2
SCHEMBL13708200 0.70 ALDH1A1 (0.49) AKR1B1MAPTCYP1A2ALDH1A1SMN1; SMN2
SCHEMBL21342234 0.69 MAPT (0.68) AKR1B1RAB9ANPC1MAPTCYP1A2
SCHEMBL21342174 0.67 AKR1B1 (0.80) AKR1B1RAB9ANPC1MAPTCYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5861400-A TREATING RESISTANCE TO AN ANTHRACYLCINE ANTIBIOTIC WITH ADIKETOPIPERAZINE COMPOUND XENOVA LIMITED (GB) 1999-01-19 US disclosed
US-5852018-A Pharmaceutical piperazine compounds XENOVA LIMITED (GB) 1998-12-22 US disclosed
EP-0672036-A1 PHARMACEUTICALLY ACTIVE DIKETOPIPERAZINES XENOVA LIMITED (GB) 1995-09-20 EP disclosed
WO-1995021831-A1 PHARMACEUTICAL PIPERAZINE COMPOUNDS XENOVA LIMITED (GB) 1995-08-17 WO disclosed
WO-1995021830-A1 PHARMACEUTICAL PIPERAZIN COMPOUNDS XENOVA LIMITED (GB) 1995-08-17 WO disclosed
WO-1994004513-A1 PHARMACEUTICALLY ACTIVE DIKETOPIPERAZINES XENOVA LIMITED (GB) 1994-03-03 WO disclosed