Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 1/20 | 0.59 |
| ▸ | DRD4 | P21917 | 2/20 | 0.58 |
| ▸ | DRD2 | P14416 | 1/20 | 0.58 |
| ▸ | DRD3 | P35462 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | HTR1B | P28222 | 1/20 | 0.46 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13246338 | 0.84 | DRD2 (0.65) | ADRB2DRD4DRD2DRD3KDM4E | |
| SCHEMBL18837443 | 0.82 | ADRB2 (0.59) | ADRB2DRD4DRD2DRD3KDM4E | |
| SCHEMBL25064148 | 0.82 | ADRB2 (0.59) | ADRB2KDM4EALDH1A1TDP1HRH3 | |
| SCHEMBL14424401 | 0.82 | ADRB2 (0.59) | ADRB2DRD4DRD2DRD3KDM4E | |
| SCHEMBL10816079 | 0.82 | ADRB2 (0.73) | ADRB2DRD4DRD2DRD3KDM4E | |
| SCHEMBL14218817 | 0.81 | ADRB2 (0.58) | ADRB2KDM4EALDH1A1MAPTTDP1 | |
| SCHEMBL8415061 | 0.80 | KDM4E (0.78) | ADRB2KDM4EALDH1A1MAPTNPSR1 | |
| SCHEMBL7694047 | 0.80 | KDM4E (0.61) | ADRB2KDM4EALDH1A1TDP1NPSR1 | |
| SCHEMBL13290628 | 0.79 | KDM4E (0.64) | ADRB2KDM4EALDH1A1TDP1HRH3 | |
| SCHEMBL12834988 | 0.79 | DRD2 (0.58) | ADRB2DRD4DRD2DRD3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5866611-A | PHENOXYPROPYLAMINE INHIBITORS OF SQUALENE SYNTHESE, USEFUL IN TREATING DISEASES IN WHICH A LOWERING OF CHOLESTEROL IS DESIRABLE. | ZENECA LIMITED (GB) | 1999-02-02 | — | — | US | disclosed |
| EP-0589018-A1 | AMINES AS INHIBITORS OF SQUALENE SYNTHASE | ZENECA LIMITED (GB) | 1994-03-30 | — | — | EP | disclosed |
| WO-1993020807-A1 | AMINES AS INHIBITORS OF SQUALENE SYNTHASE | ZENECA LIMITED (GB) | 1993-10-28 | — | — | WO | disclosed |