Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGIR | P43119 | 8/20 | 0.55 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8414274 | 0.88 | SIGMAR1 (0.46) | PTGIRSIGMAR1HTR1AADRA1A | |
| SCHEMBL8414275 | 0.81 | PTGIR (0.54) | PTGIR | |
| SCHEMBL8412769 | 0.79 | PTGIR (0.59) | PTGIRTBXAS1SIGMAR1 | |
| SCHEMBL9155480 | 0.78 | PTGIR (0.68) | PTGIRTBXAS1SIGMAR1 | |
| SCHEMBL9155513 | 0.76 | PTGIR (0.69) | PTGIRTBXAS1SIGMAR1 | |
| SCHEMBL8410505 | 0.75 | PTGIR (0.59) | PTGIR | |
| SCHEMBL8858587 | 0.74 | PTGIR (0.72) | PTGIRTBXAS1SIGMAR1HTR1A | |
| SCHEMBL9050868 | 0.73 | PTGIR (0.64) | PTGIRTBXAS1 | |
| SCHEMBL9017264 | 0.72 | PTGIR (0.63) | PTGIRTBXAS1 | |
| SCHEMBL9151307 | 0.72 | PTGIR (0.63) | PTGIRTBXAS1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0548949-B1 | Fused benzeneoxyacetic acid derivatives | ONO PHARMACEUTICAL CO (JP) | 1997-09-17 | — | — | EP | claimed |
| EP-0548949-A2 | Fused benzeneoxyacetic acid derivatives | ONO PHARMACEUTICAL CO., LTD. (JP) | 1993-06-30 | — | — | EP | claimed |
| US-5962439-A | CARDIOVASCULAR DISORDER | ONO PHARMACEUTICAL CO., LTD. (JP) | 1999-10-05 | — | — | US | disclosed |
| US-5849919-A | Fused benzeneoxyacetic acid derivatives which have PGI2 receptor anonist activity | ONO PHARMACEUTICAL CO., LTD. (JP) | 1998-12-15 | — | — | US | disclosed |
| EP-0548949-B1 | Fused benzeneoxyacetic acid derivatives | ONO PHARMACEUTICAL CO (JP) | 1997-09-17 | — | — | EP | disclosed |
| US-5589496-A | Fused benzeneoxyacetic acid derivatives which have PGI2 receptor agonist activity | ONO PHARMACEUTICAL CO., LTD. (JP) | 1996-12-31 | — | — | US | disclosed |
| US-5389666-A | Administering for treatment and prevention of thrombosis, arteriosclerosis, ischemic heart diseases, gastric ulcer or hypertension | ONO PHARMACEUTICAL CO., LTD. (JP) | 1995-02-14 | — | — | US | disclosed |
| EP-0548949-A2 | Fused benzeneoxyacetic acid derivatives | ONO PHARMACEUTICAL CO., LTD. (JP) | 1993-06-30 | — | — | EP | disclosed |