Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 15/20 | 0.61 |
| ▸ | PPARG | P37231 | 3/20 | 0.57 |
| ▸ | PPARA | Q07869 | 3/20 | 0.57 |
| ▸ | PPARD | Q03181 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8414370 | 1.00 | ACE (0.61) | ACEPPARGPPARAPPARD | |
| SCHEMBL8414708 | 0.89 | ACE (0.51) | ACEPPARGPPARAPPARD | |
| SCHEMBL8414944 | 0.81 | HDAC3 (0.39) | ACEPPARGPPARA | |
| SCHEMBL8410793 | 0.79 | CASP1 (0.55) | ACEPPARGPPARA | |
| SCHEMBL29498364 | 0.78 | ACE (0.48) | ACE | |
| SCHEMBL5853138 | 0.77 | PPARA (0.90) | ACEPPARGPPARAPPARD | |
| SCHEMBL3362562 | 0.77 | PPARA (0.90) | ACEPPARGPPARAPPARD | |
| SCHEMBL3582418 | 0.77 | PPARA (0.90) | ACEPPARGPPARAPPARD | |
| SCHEMBL18342569 | 0.76 | CTSK (0.55) | PPARA | |
| SCHEMBL20263594 | 0.76 | CTSK (0.55) | PPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0932598-A1 | ASPARTATE ESTER INHIBITORS OF INTERLEUKIN-1$g(b) CONVERTING ENZYME | WARNER-LAMBERT COMPANY (US) | 1999-08-04 | — | — | EP | disclosed |
| WO-1998016502-A1 | ASPARTATE ESTER INHIBITORS OF INTERLEUKIN-1β CONVERTING ENZYME | WARNER-LAMBERT COMPANY (US) | 1998-04-23 | — | — | WO | disclosed |