Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 6/20 | 0.51 |
| ▸ | PPARG | P37231 | 3/20 | 0.48 |
| ▸ | PPARA | Q07869 | 3/20 | 0.48 |
| ▸ | CASP3 | P42574 | 10/20 | 0.46 |
| ▸ | CASP8 | Q14790 | 8/20 | 0.46 |
| ▸ | CASP1 | P29466 | 5/20 | 0.46 |
| ▸ | CASP7 | P55210 | 5/20 | 0.46 |
| ▸ | PPARD | Q03181 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8414370 | 0.89 | ACE (0.61) | ACEPPARGPPARAPPARD | |
| SCHEMBL8414368 | 0.89 | ACE (0.61) | ACEPPARGPPARAPPARD | |
| SCHEMBL8413468 | 0.83 | PPARG (0.46) | ACEPPARGPPARACASP3CASP8 | |
| SCHEMBL8413555 | 0.81 | CYP2D6 (0.34) | — | |
| SCHEMBL8410793 | 0.80 | CASP1 (0.55) | ACEPPARGPPARACASP3CASP8 | |
| SCHEMBL17261861 | 0.78 | CTSK (0.52) | CASP1 | |
| SCHEMBL6158897 | 0.78 | MMP9 (0.45) | CASP1 | |
| SCHEMBL7428604 | 0.78 | MMP9 (0.45) | CASP1 | |
| SCHEMBL79537 | 0.77 | CASP1 (0.54) | PPARACASP1 | |
| SCHEMBL79538 | 0.77 | CASP1 (0.54) | PPARACASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0932598-A1 | ASPARTATE ESTER INHIBITORS OF INTERLEUKIN-1$g(b) CONVERTING ENZYME | WARNER-LAMBERT COMPANY (US) | 1999-08-04 | — | — | EP | disclosed |
| WO-1998016502-A1 | ASPARTATE ESTER INHIBITORS OF INTERLEUKIN-1β CONVERTING ENZYME | WARNER-LAMBERT COMPANY (US) | 1998-04-23 | — | — | WO | disclosed |