Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.65 |
| ▸ | PLA2G4B | P0C869 | 3/20 | 0.63 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.60 |
| ▸ | SMPD1 | P17405 | 3/20 | 0.59 |
| ▸ | THRB | P10828 | 2/20 | 0.58 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.56 |
| ▸ | THRA | P10827 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.53 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.53 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9402738 | 0.94 | SMPD1 (0.68) | KMT2APLA2G4BNR1H4SMPD1THRB | |
| SCHEMBL3315904 | 0.87 | KMT2A (0.84) | KMT2APLA2G4BNR1H4SMPD1PTPN11 | |
| SCHEMBL8414532 | 0.86 | KMT2A (0.59) | KMT2APLA2G4BNR1H4SMPD1THRB | |
| SCHEMBL30016648 | 0.86 | SMPD1 (0.74) | KMT2APLA2G4BNR1H4SMPD1THRB | |
| SCHEMBL16196481 | 0.86 | SMPD1 (0.74) | KMT2APLA2G4BNR1H4SMPD1THRB | |
| SCHEMBL18917586 | 0.84 | LMNA (0.69) | KMT2APLA2G4BNR1H4SMPD1THRB | |
| SCHEMBL1436145 | 0.84 | THRB (0.65) | KMT2APLA2G4BNR1H4SMPD1THRB | |
| SCHEMBL27903063 | 0.84 | KMT2A (0.64) | KMT2APLA2G4BNR1H4SMPD1THRB | |
| SCHEMBL2455314 | 0.84 | KMT2A (0.84) | KMT2APLA2G4BNR1H4SMPD1THRB | |
| SCHEMBL31135466 | 0.84 | KMT2A (0.56) | KMT2APLA2G4BNR1H4SMPD1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007016012-A2 | CYCLOALKYL AMINO-HYDANTOIN COMPOUNDS AND USE THEREOF FOR β-SECRETASE MODULATION | WYETH (US) | 2007-02-08 | — | — | WO | disclosed |
| US-20070027199-A1 | Cycloalkyl amino-hydantoin compounds and use thereof for beta-secretase modulation | WYETH (US) | 2007-02-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070027199-A1 | Cycloalkyl amino-hydantoin compounds and use thereof for beta-secretase modulation | BACE1, BACE2, APP | KMT2A 1445/4885PLA2G4B 603/4885NR1H4 1581/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.