Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | AGO2 | Q9UKV8 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | CYTH2 | Q99418 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8413157 | 0.90 | HTR6 (0.57) | HTR6GAAALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL7823751 | 0.83 | HTR6 (0.74) | HTR6GAAALDH1A1KDM4ELMNA | |
| SCHEMBL7836239 | 0.79 | PKM (0.60) | GAAALDH1A1KDM4ELMNATSHR | |
| SCHEMBL4515051 | 0.77 | TSHR (0.71) | GAAALDH1A1KDM4ELMNATSHR | |
| SCHEMBL11757838 | 0.77 | PDE4A (0.69) | ALDH1A1KDM4ELMNAPDE4AAGO2 | |
| SCHEMBL8413230 | 0.74 | CES1 (0.44) | HTR6GAAALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL17682474 | 0.73 | TSHR (0.70) | GAAALDH1A1KDM4ELMNATSHR | |
| SCHEMBL17593130 | 0.72 | TSHR (0.76) | GAAALDH1A1KDM4ELMNATSHR | |
| SCHEMBL482662 | 0.72 | CA12 (0.62) | GAAALDH1A1LMNASMN1; SMN2TDP1 | |
| SCHEMBL7824815 | 0.71 | CES1 (0.62) | HTR6GAAALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5939451-A | INDOL-4-YL-BENZENESULFONAMIDES AS ACTIVE MATERIAL TREATING MALARIA, BACTERIAL INFECTION, NEUROLOGICAL DISORDERS | HOFFMANN-LA ROCHE INC. (US) | 1999-08-17 | — | — | US | disclosed |
| US-5932599-A | 4-AMINO-N-(PYRIDINYL-4-YL)-BENZENESULFONAMIDES AS ACTIVE MATERIAL TREATING MALARIA, BACTERIAL INFECTION, NEUROLOGICAL DISORDERS | HOFFMANN-LA ROCHE INC. (US) | 1999-08-03 | — | — | US | disclosed |