Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | AKT1 | P31749 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | GFER | P55789 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7837467 | 0.92 | LMNA (0.63) | PKMSMN1; SMN2LMNAKDM4EALDH1A1 | |
| SCHEMBL29776905 | 0.82 | TSHR (0.73) | SMN1; SMN2LMNATSHRNPSR1ALDH1A1 | |
| SCHEMBL7823751 | 0.81 | HTR6 (0.74) | SMN1; SMN2LMNANPSR1KDM4EALDH1A1 | |
| SCHEMBL8414792 | 0.79 | HTR6 (0.51) | SMN1; SMN2LMNATSHRKDM4EALDH1A1 | |
| SCHEMBL7833408 | 0.79 | LMNA (0.63) | PKMSMN1; SMN2LMNAKDM4EALDH1A1 | |
| SCHEMBL17593131 | 0.78 | SMN1; SMN2 (0.69) | SMN1; SMN2LMNATSHRNPSR1ALDH1A1 | |
| SCHEMBL7574036 | 0.77 | PKM (0.68) | PKMSMN1; SMN2LMNAKDM4EALDH1A1 | |
| SCHEMBL9365750 | 0.76 | PKM (0.73) | PKMSMN1; SMN2LMNAKDM4EALDH1A1 | |
| SCHEMBL7138572 | 0.75 | PKM (0.62) | PKMALDH1A1KMT2AGAA | |
| SCHEMBL7834756 | 0.75 | LMNA (0.66) | PKMSMN1; SMN2LMNAKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0815861-B1 | Sulphonamides and their use | HOFFMANN LA ROCHE (CH) | 2001-09-19 | — | — | EP | disclosed |
| US-6030976-A | SELECTIVE AFFINITY TO 5HT-6 RECEPTORS; CENTRAL NERVOUS SYSTEM DISORDERS; ALZHEIMER'S DISEASE, PSYCHOSES, SCHIZOPHRENIA, MANIC DEPRESSIONS, MEMORY DISORDERS, PARKINSON'S DISEASE, AMYOTROPHIC LATERAL SCLEROSIS AND HUNTINGTON'S DISEASE | HOFFMAN-LA ROCHE INC. (US) | 2000-02-29 | — | — | US | disclosed |
| US-5998665-A | THERAPY FOR NERVOUS SYSTEM DISORDERS | HOFFMANN-LA ROCHE INC. (US) | 1999-12-07 | — | — | US | disclosed |
| EP-0815861-A1 | Sulphonamides and their use | F. HOFFMANN-LA ROCHE AG (CH) | 1998-01-07 | — | — | EP | disclosed |