Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Urea. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.33 |
| ▸ | OR51E2 | Q9H255 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | LDHA | P00338 | 1/20 | 0.30 |
| ▸ | LDHB | P07195 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Urea SCHEMBL187900 | 0.94 | OR51E2 (0.40) | OR51E2ALDH1A1LMNATDP1ACHE | |
| Urea SCHEMBL29246848 | 0.83 | ALDH1A1 (0.32) | OR51E2ALDH1A1LMNATDP1ACHE | |
| Urea SCHEMBL28419726 | 0.78 | CAMK2A (0.32) | OR51E2ALDH1A1LMNATDP1ACHE | |
| SCHEMBL510195 | 0.77 | — | — | |
| Urea SCHEMBL5032726 | 0.71 | LMNA (0.39) | OR51E2ALDH1A1LMNATDP1ACHE | |
| Glycolic Acid SCHEMBL27867705 | 0.70 | — | — | |
| Carbamic Acid SCHEMBL29228035 | 0.69 | — | — | |
| Urea SCHEMBL6361905 | 0.69 | — | — | |
| Urea SCHEMBL5081616 | 0.65 | — | — | |
| Urea SCHEMBL8004035 | 0.64 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5948120-A | Process for producing a controlled rumpled effect to denim or twill garments | SIGHTS DENIM SYSTEMS, INC. (US) | 1999-09-07 | — | — | US | claimed |