Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.39 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.39 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9677441 | 0.89 | PTPN1 (0.41) | TSHRALDH1A1KDM4EHPGDPTPN1 | |
| SCHEMBL6824035 | 0.79 | TSHR (0.71) | TSHRALDH1A1KDM4EHPGDL3MBTL1 | |
| SCHEMBL4089116 | 0.76 | SMN1; SMN2 (0.52) | TSHRALDH1A1KDM4EHPGDMAPT | |
| SCHEMBL24453339 | 0.74 | PPARG (0.48) | TSHRHPGDSMN1; SMN2ALOX15MEN1 | |
| SCHEMBL2314666 | 0.73 | TSHR (0.56) | TSHRALDH1A1KDM4EHPGDMAPT | |
| SCHEMBL18050527 | 0.72 | MAPK1 (0.48) | TSHRKDM4EMAPTLMNAHTT | |
| SCHEMBL10665205 | 0.72 | TSHR (0.58) | TSHRALDH1A1KDM4EHPGDMAPT | |
| SCHEMBL17375002 | 0.71 | ALDH1A1 (0.42) | TSHRALDH1A1KDM4EHPGDL3MBTL1 | |
| SCHEMBL13651187 | 0.71 | KDM4E (0.45) | ALDH1A1KDM4EL3MBTL1LMNASMN1; SMN2 | |
| SCHEMBL15124569 | 0.71 | ADORA2A (0.49) | TSHRALDH1A1KDM4EHPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0682017-B1 | Substituted bicycle heteroaroylguanidines, their preparation and their application in medicaments and diagnostic agents | HOECHST AG (DE) | 1999-08-11 | — | — | EP | disclosed |
| EP-0682017-A1 | Substituted bicycle heteroaroylguanidines, their preparation and their application in medicaments and diagnostic agents | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-11-15 | — | — | EP | disclosed |