Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 2/20 | 0.45 |
| ▸ | HTR2C | P28335 | 2/20 | 0.45 |
| ▸ | HTR2B | P41595 | 2/20 | 0.45 |
| ▸ | F10 | P00742 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CCR3 | P51677 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8866360 | 0.89 | HTR4 (0.51) | ALDH1A1MEN1KMT2AHTR2AHTR2C | |
| SCHEMBL8417837 | 0.82 | KCNH2 (0.45) | HTR2AHTR2CHTR2BL3MBTL1DRD2 | |
| SCHEMBL8416209 | 0.78 | KCNH2 (0.45) | ALDH1A1SMN1; SMN2LMNAHTR2AHTR2C | |
| SCHEMBL8865738 | 0.78 | KCNH2 (0.52) | ALDH1A1SMN1; SMN2LMNAHTR2AHTR2C | |
| SCHEMBL8417804 | 0.77 | DRD3 (0.50) | ALDH1A1SMN1; SMN2LMNAHTR2AHTR2B | |
| SCHEMBL8866229 | 0.76 | HTR4 (0.64) | ALDH1A1MEN1KMT2AHTR2AHTR2C | |
| SCHEMBL20069763 | 0.75 | PIN1 (0.48) | SMN1; SMN2NPC1RAB9ALMNAMEN1 | |
| SCHEMBL8866468 | 0.73 | KCNH2 (0.48) | ALDH1A1SMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL8865630 | 0.73 | HTR4 (0.52) | ALDH1A1SMN1; SMN2LMNAHTR2AHTR2C | |
| SCHEMBL29904381 | 0.73 | HTR4 (0.52) | ALDH1A1SMN1; SMN2NPC1RAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0650475-B1 | 4-AMINO-N-(4-METHYL-4-PIPERIDINYL)-2-METHOXYBENZAMIDES, THEIR PREPARATION AND THEIR USE AS 5-HT2 ANTAGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 1999-09-01 | — | — | EP | claimed |
| EP-0650475-B1 | 4-AMINO-N-(4-METHYL-4-PIPERIDINYL)-2-METHOXYBENZAMIDES, THEIR PREPARATION AND THEIR USE AS 5-HT2 ANTAGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 1999-09-01 | — | — | EP | disclosed |