SCHEMBL8415489

SCHEMBL8415489

CC(C)(c1ccccc1)c1cccc(C(C)(C)c2cccc(-n3nc4ccccc4n3)c2)c1O

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 8/20 0.45
HPGD P15428 6/20 0.45
PPARG P37231 1/20 0.40
PPARA Q07869 1/20 0.40
ESR1 P03372 2/20 0.37
ESR2 Q92731 2/20 0.37
NPC1 O15118 9/20 0.37
RAB9A P51151 9/20 0.37
ALDH1A1 P00352 7/20 0.37
MAPT P10636 3/20 0.37
MEN1 O00255 2/20 0.37
KMT2A Q03164 2/20 0.37
STAT1 P42224 1/20 0.37
SMN1; SMN2 Q16637 6/20 0.37
HSD17B10 Q99714 3/20 0.37
NPSR1 Q6W5P4 2/20 0.37
MAPK1 P28482 1/20 0.37
TP53 P04637 2/20 0.36
GAA P10253 2/20 0.36
NFKB1 P19838 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9488921 0.90 ALDH1A1 (0.44) KDM4EHPGDPPARGPPARAESR1
SCHEMBL4398146 0.88 KDM4E (0.36) KDM4EHPGDPPARGPPARAESR1
SCHEMBL4159028 0.86 PPARG (0.46) KDM4EHPGDPPARGPPARAESR1
SCHEMBL11470802 0.84 CNR1 (0.35) KDM4EHPGDPPARGPPARACNR1
SCHEMBL29904482 0.82 NPC1 (0.41) KDM4EHPGDPPARGPPARAESR1
SCHEMBL20272359 0.82 NPC1 (0.41) KDM4EHPGDPPARGPPARAESR1
SCHEMBL3680277 0.80 PPARG (0.41) KDM4EHPGDPPARGPPARAESR1
SCHEMBL29351747 0.80 PPARG (0.41) KDM4EHPGDPPARGPPARAESR1
SCHEMBL28507848 0.79 KDM4E (0.41) KDM4EHPGDPPARGPPARAESR1
SCHEMBL27341518 0.78 GABRA1 (0.45) KDM4EHPGDPPARGPPARAESR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0934987-A1 Primer composition SHIN-ETSU CHEMICAL CO., LTD. (JP) 1999-08-11 EP claimed
EP-0187491-B1 CORROSION-RESISTANT SILVER MIRROR MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1989-05-10 EP claimed
EP-2995466-A1 HEAT-SENSITIVE RECORDING MEDIUM DISPLAYING GOLD METAL TONE, AND/OR HEAT-SENSITIVE RECORDING MEDIUM DISPLAYING TWO DIFFERENT COLOR TONES Oji Holdings Corporation (JP) 2016-03-16 EP disclosed