Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 6/20 | 0.53 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.53 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.53 |
| ▸ | HTR2A | P28223 | 4/20 | 0.47 |
| ▸ | DRD2 | P14416 | 4/20 | 0.47 |
| ▸ | HTR7 | P34969 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | DRD4 | P21917 | 3/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8416472 | 0.87 | KDM4E (0.61) | HTR1AADRA1DADRA1AADRA1BHTR2A | |
| SCHEMBL8416539 | 0.84 | HTR2A (0.55) | HTR1AADRA1AHTR2ADRD2HTR7 | |
| SCHEMBL8416503 | 0.82 | HTR1A (0.61) | HTR1AHTR2ADRD2HTR7DRD3 | |
| SCHEMBL8416455 | 0.82 | HTR1A (0.62) | HTR1AADRA1DADRA1AADRA1BHTR2A | |
| SCHEMBL8418004 | 0.77 | HTR1A (0.48) | HTR1AHTR2ADRD2HTR7DRD4 | |
| SCHEMBL3196223 | 0.75 | HTR1A (0.57) | HTR1AADRA1DADRA1AADRA1BHTR2A | |
| SCHEMBL8417661 | 0.74 | HTR2A (0.58) | HTR1AADRA1DADRA1BHTR2ADRD2 | |
| SCHEMBL8416451 | 0.74 | HTR1A (0.56) | HTR1AADRA1DADRA1AADRA1BHTR2A | |
| SCHEMBL8418003 | 0.74 | HSD17B10 (0.56) | HTR1AADRA1DADRA1AADRA1BHTR2A | |
| SCHEMBL7968237 | 0.73 | CYP2D6 (0.58) | HTR1AADRA1DADRA1AADRA1BHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0655248-B1 | Use of 1-4-4-aryl(or heteroaryl)-1-piperazinylbutyl-1H-azole derivatives for the preparation of medicaments for the treatment of disorders of gastric secretion | ESTEVE LABOR DR (ES) | 1999-09-15 | — | — | EP | claimed |
| EP-0808166-A1 | MEDICAMENT INTENDED TO THE TREATMENT OF OBSESSIVE COMPULSIVE TROUBLES, SLEEP APNOEA, SEXUAL DYSFUNCTIONS, EMESA AND TRANSPORT SICKNESS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 1997-11-26 | — | — | EP | claimed |
| WO-1997021439-A1 | MEDICAMENT INTENDED TO THE TREATMENT OF OBSESSIVE COMPULSIVE TROUBLES, SLEEP APNOEA, SEXUAL DYSFUNCTIONS, EMESA AND TRANSPORT SICKNESS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 1997-06-19 | — | — | WO | claimed |
| US-5532234-A | Use of 1-[4-[4-aryl (or heteroaryl)-1-piperazinyl]-butyl)-1H-azole derivatives for the preparation of medicaments intended for the treatment of disorders of gastric secretion | LABORATORIES DEL DR. ESTEVE, S.A. (ES) | 1996-07-02 | — | — | US | claimed |
| EP-0808166-A1 | MEDICAMENT INTENDED TO THE TREATMENT OF OBSESSIVE COMPULSIVE TROUBLES, SLEEP APNOEA, SEXUAL DYSFUNCTIONS, EMESA AND TRANSPORT SICKNESS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 1997-11-26 | — | — | EP | disclosed |
| WO-1997021439-A1 | MEDICAMENT INTENDED TO THE TREATMENT OF OBSESSIVE COMPULSIVE TROUBLES, SLEEP APNOEA, SEXUAL DYSFUNCTIONS, EMESA AND TRANSPORT SICKNESS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 1997-06-19 | — | — | WO | disclosed |