Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 6/20 | 0.48 |
| ▸ | DRD2 | P14416 | 6/20 | 0.48 |
| ▸ | HTR2A | P28223 | 4/20 | 0.48 |
| ▸ | DRD3 | P35462 | 5/20 | 0.47 |
| ▸ | DRD1 | P21728 | 2/20 | 0.47 |
| ▸ | DRD5 | P21918 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
| ▸ | DRD4 | P21917 | 1/20 | 0.45 |
| ▸ | HTR7 | P34969 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7474002 | 0.86 | SIGMAR1 (0.53) | HTR1ADRD2 | |
| SCHEMBL8115703 | 0.86 | HTR1A (0.41) | HTR1ADRD2HTR2AHTR7ALDH1A1 | |
| Citric Acid SCHEMBL9025029 | 0.86 | HRH3 (0.42) | HTR1ADRD2HTR2ADRD3HRH3 | |
| Hydrochloric Acid SCHEMBL8115889 | 0.85 | HTR1A (0.40) | HTR1ADRD2HTR2AHTR7ALDH1A1 | |
| SCHEMBL8416472 | 0.82 | KDM4E (0.61) | HTR1ADRD2HTR2ADRD3DRD1 | |
| SCHEMBL8416503 | 0.82 | HTR1A (0.61) | HTR1ADRD2HTR2ADRD3HTR7 | |
| SCHEMBL8113668 | 0.81 | ALDH1A1 (0.47) | HTR1AHTR7ALDH1A1 | |
| SCHEMBL8416539 | 0.79 | HTR2A (0.55) | HTR1ADRD2HTR2ADRD3HTR7 | |
| SCHEMBL8416338 | 0.78 | P2RX7 (0.63) | HTR1ADRD2HTR2ADRD3DRD1 | |
| SCHEMBL8416455 | 0.77 | HTR1A (0.62) | HTR1ADRD2HTR2ADRD3HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0655248-B1 | Use of 1-4-4-aryl(or heteroaryl)-1-piperazinylbutyl-1H-azole derivatives for the preparation of medicaments for the treatment of disorders of gastric secretion | ESTEVE LABOR DR (ES) | 1999-09-15 | — | — | EP | claimed |
| US-5532234-A | Use of 1-[4-[4-aryl (or heteroaryl)-1-piperazinyl]-butyl)-1H-azole derivatives for the preparation of medicaments intended for the treatment of disorders of gastric secretion | LABORATORIES DEL DR. ESTEVE, S.A. (ES) | 1996-07-02 | — | — | US | claimed |
| EP-0502786-B1 | Process for the preparation of aryl(or heteroaryl)-piperazin-1-butyl-azole derivatives | ESTEVE LABOR DR (ES) | 1996-04-24 | — | — | EP | claimed |
| EP-0497659-B1 | Aryl(or Heteroaryl)-piperazinyl-alkyl-azole derivatives, their preparation and their application as drugs | ESTEVE LABOR DR (ES) | 1996-04-10 | — | — | EP | claimed |
| EP-0502786-B1 | Process for the preparation of aryl(or heteroaryl)-piperazin-1-butyl-azole derivatives | ESTEVE LABOR DR (ES) | 1996-04-24 | — | — | EP | disclosed |
| EP-0497659-B1 | Aryl(or Heteroaryl)-piperazinyl-alkyl-azole derivatives, their preparation and their application as drugs | ESTEVE LABOR DR (ES) | 1996-04-10 | — | — | EP | disclosed |
| US-5382586-A | Tranquilizers | LABORATORIOS DEL DR. ESTEVE S.A. (ES) | 1995-01-17 | — | — | US | disclosed |
| US-5292739-A | Aryl(or heteroaryl) piperazinylalkylazole derivatives, their preparation and their application as medicaments | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 1994-03-08 | — | — | US | disclosed |
| US-5227486-A | Reaction of spiro-quaternary ammonium compound | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 1993-07-13 | — | — | US | disclosed |
| EP-0502786-A1 | Process for the preparation of aryl(or heteroaryl)-piperazin-1-butyl-azole derivatives | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 1992-09-09 | — | — | EP | disclosed |
| EP-0497659-A1 | Aryl(or Heteroaryl)-piperazinyl-alkyl-azole derivatives, their preparation and their application as drugs | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 1992-08-05 | — | — | EP | disclosed |