Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | DRD2 | P14416 | 7/20 | 0.53 |
| ▸ | HTR1A | P08908 | 5/20 | 0.50 |
| ▸ | HTR2A | P28223 | 5/20 | 0.50 |
| ▸ | HTR7 | P34969 | 4/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.50 |
| ▸ | DRD4 | P21917 | 2/20 | 0.48 |
| ▸ | HTR6 | P50406 | 2/20 | 0.48 |
| ▸ | SOD1 | P00441 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8416503 | 0.85 | HTR1A (0.61) | DRD2HTR1AHTR2AHTR7KCNH2 | |
| SCHEMBL8416455 | 0.81 | HTR1A (0.62) | HSD17B10DRD2HTR1AHTR2AHTR7 | |
| SCHEMBL8416472 | 0.78 | KDM4E (0.61) | DRD2HTR1AHTR2AHTR7ADRA1A | |
| SCHEMBL8418004 | 0.76 | HTR1A (0.48) | DRD2HTR1AHTR2AHTR7DRD4 | |
| SCHEMBL10994325 | 0.76 | HSD17B10 (0.73) | HSD17B10DRD2HTR1AHTR2AHTR7 | |
| SCHEMBL16303868 | 0.76 | DRD2 (0.79) | HSD17B10DRD2HTR1AHTR2AHTR7 | |
| SCHEMBL8416539 | 0.75 | HTR2A (0.55) | DRD2HTR1AHTR2AHTR7ADRA1A | |
| SCHEMBL8416352 | 0.75 | SIGMAR1 (0.57) | DRD2HTR1AHTR7ADRA1ADRD3 | |
| SCHEMBL3186225 | 0.74 | HSD17B10 (0.91) | HSD17B10DRD2HTR1AHTR2AHTR7 | |
| SCHEMBL18937451 | 0.74 | DRD2 (0.82) | HSD17B10DRD2HTR1AHTR2AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0655248-B1 | Use of 1-4-4-aryl(or heteroaryl)-1-piperazinylbutyl-1H-azole derivatives for the preparation of medicaments for the treatment of disorders of gastric secretion | ESTEVE LABOR DR (ES) | 1999-09-15 | — | — | EP | claimed |
| EP-0502786-B1 | Process for the preparation of aryl(or heteroaryl)-piperazin-1-butyl-azole derivatives | ESTEVE LABOR DR (ES) | 1996-04-24 | — | — | EP | claimed |
| EP-0497659-B1 | Aryl(or Heteroaryl)-piperazinyl-alkyl-azole derivatives, their preparation and their application as drugs | ESTEVE LABOR DR (ES) | 1996-04-10 | — | — | EP | claimed |
| EP-0655248-A1 | Use of 1-4-4-aryl(or heteroaryl)-1-piperazinylbutyl-1H-azole derivatives for the preparation of medicaments for the treatment of disorders of gastric secretion | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 1995-05-31 | — | — | EP | claimed |
| EP-0502786-A1 | Process for the preparation of aryl(or heteroaryl)-piperazin-1-butyl-azole derivatives | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 1992-09-09 | — | — | EP | claimed |
| EP-0497659-A1 | Aryl(or Heteroaryl)-piperazinyl-alkyl-azole derivatives, their preparation and their application as drugs | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 1992-08-05 | — | — | EP | claimed |