SCHEMBL8417148

SCHEMBL8417148

CC(C)c1ccccc1Nc1ccc(-c2ccc(Nc3ccccc3C(C)C)cc2-c2ccccc2)c(-c2ccccc2)c1

nearest known ligand 0.40

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 1/20 0.39
S1PR1 P21453 1/20 0.37
CCR4 P51679 1/20 0.37
PIK3CA P42336 1/20 0.36
PIK3CB P42338 1/20 0.36
PIK3CG P48736 1/20 0.36
POLB P06746 1/20 0.36
RORC P51449 1/20 0.36
APP P05067 1/20 0.36
CA12 O43570 1/20 0.35
CA1 P00915 1/20 0.35
CA2 P00918 1/20 0.35
CA9 Q16790 1/20 0.35
EGFR P00533 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8418919 0.85 TSHR (0.39) L3MBTL1RORCAPP
SCHEMBL19773093 0.82 L3MBTL1 (0.44) L3MBTL1CCR4PIK3CAPIK3CBPIK3CG
SCHEMBL9006076 0.79 MAPK14 (0.44) APP
SCHEMBL8417151 0.79 PIK3CA (0.36) L3MBTL1CCR4PIK3CAPIK3CBPIK3CG
SCHEMBL30285203 0.78 ALDH1A1 (0.53) L3MBTL1CCR4POLB
SCHEMBL5686057 0.78 L3MBTL1 (0.47) L3MBTL1CCR4PIK3CAPIK3CBPIK3CG
SCHEMBL24082160 0.78 CDC25B (0.38) L3MBTL1APP
SCHEMBL7979001 0.77 TDP1 (0.50) L3MBTL1CCR4POLB
SCHEMBL20067360 0.77 ALDH1A1 (0.53) L3MBTL1CCR4PIK3CAPIK3CBPIK3CG
SCHEMBL25125190 0.76 FABP3 (0.47) APPCA12CA1CA2CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0597128-B1 ESTER POLYMER, PRODUCTION THEREOF, AND ELECTROPHOTOGRAPHIC PHOTORECEPTOR MADE THEREFROM IDEMITSU KOSAN CO (JP) 1999-09-15 EP disclosed
EP-0582722-B1 ELECTROPHOTOGRAPHIC PHOTORECEPTOR MADE FROM POLYCARBONATE POLYMER IDEMITSU KOSAN CO (JP) 1997-11-12 EP disclosed
EP-0411192-B1 Electrophotographic photoreceptor IDEMITSU KOSAN CO (JP) 1995-06-07 EP disclosed
EP-0597128-A1 ESTER POLYMER, PRODUCTION THEREOF, AND ELECTROPHOTOGRAPHIC PHOTORECEPTOR MADE THEREFROM IDEMITSU KOSAN COMPANY LIMITED (JP) 1994-05-18 EP disclosed
EP-0582722-A1 POLYCARBONATE POLYMER, PRODUCTION THEREOF, AND ELECTROPHOTOGRAPHIC PHOTORECEPTOR MADE THEREFROM IDEMITSU KOSAN COMPANY LIMITED (JP) 1994-02-16 EP disclosed
EP-0411192-A1 Electrophotographic photoreceptor IDEMITSU KOSAN COMPANY LIMITED (JP) 1991-02-06 EP disclosed