Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.34 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.34 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8421782 | 0.88 | ALDH1A1 (0.38) | MAPTALDH1A1TSHRKDM4ELMNA | |
| SCHEMBL8417850 | 0.84 | KMT2A (0.39) | MAPTALDH1A1TSHRKDM4EHPGD | |
| SCHEMBL8417863 | 0.81 | ALDH1A1 (0.39) | MAPTALDH1A1TSHRKDM4ELMNA | |
| SCHEMBL8417450 | 0.81 | MAPT (0.36) | MAPTALDH1A1TSHRKDM4ELMNA | |
| SCHEMBL8357062 | 0.81 | ALDH1A1 (0.36) | MAPTALDH1A1TSHRKDM4ELMNA | |
| SCHEMBL8417854 | 0.79 | ALDH1A1 (0.43) | MAPTALDH1A1TSHRKDM4ELMNA | |
| SCHEMBL8419470 | 0.78 | MAPT (0.42) | MAPTALDH1A1KDM4ELMNAL3MBTL1 | |
| SCHEMBL8363466 | 0.78 | MAPT (0.39) | MAPTALDH1A1KDM4ELMNAL3MBTL1 | |
| SCHEMBL8868610 | 0.75 | PARP1 (0.36) | ALDH1A1TSHRKDM4ELMNAHPGD | |
| SCHEMBL8419218 | 0.74 | MEN1 (0.38) | MAPTALDH1A1TSHRKDM4ETDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5962491-A | ANGIOTENSIN ANTAGONIST, HYPOTENSIVE AGENTS, CARDIOVASCULAR DISORDERS, STROKES | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1999-10-05 | — | — | US | disclosed |
| US-5705517-A | ANGIOTENSIN II ANTAGONISTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-01-06 | — | — | US | disclosed |
| US-5703110-A | HYPOTENSIVE AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-12-30 | — | — | US | disclosed |