Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.43 |
| ▸ | HPGD | P15428 | 5/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | CFTR | P13569 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8417863 | 0.92 | ALDH1A1 (0.39) | ALDH1A1KDM4ETDP1HPGDL3MBTL1 | |
| SCHEMBL8357062 | 0.86 | ALDH1A1 (0.36) | ALDH1A1KDM4ETDP1HPGDL3MBTL1 | |
| SCHEMBL8421782 | 0.86 | ALDH1A1 (0.38) | ALDH1A1KDM4ETDP1HPGDL3MBTL1 | |
| SCHEMBL8421724 | 0.85 | KDM4E (0.34) | ALDH1A1KDM4ETDP1HPGDL3MBTL1 | |
| SCHEMBL8417850 | 0.83 | KMT2A (0.39) | ALDH1A1KDM4ETDP1HPGDL3MBTL1 | |
| SCHEMBL8417450 | 0.82 | MAPT (0.36) | ALDH1A1KDM4ETDP1HPGDL3MBTL1 | |
| SCHEMBL8417430 | 0.79 | MAPT (0.37) | ALDH1A1KDM4ETDP1HPGDL3MBTL1 | |
| SCHEMBL8419218 | 0.76 | MEN1 (0.38) | ALDH1A1KDM4ETDP1L3MBTL1NPSR1 | |
| SCHEMBL7376271 | 0.76 | ALDH1A1 (0.42) | ALDH1A1KDM4ETDP1HPGDL3MBTL1 | |
| SCHEMBL7010550 | 0.74 | MAPT (0.36) | ALDH1A1KDM4ETDP1L3MBTL1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5962491-A | ANGIOTENSIN ANTAGONIST, HYPOTENSIVE AGENTS, CARDIOVASCULAR DISORDERS, STROKES | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1999-10-05 | — | — | US | disclosed |
| US-5705517-A | ANGIOTENSIN II ANTAGONISTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-01-06 | — | — | US | disclosed |
| US-5703110-A | HYPOTENSIVE AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-12-30 | — | — | US | disclosed |