Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | EIF4E | P06730 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | DHODH | Q02127 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8419218 | 0.90 | MEN1 (0.38) | KMT2AMEN1MAPTALDH1A1TSHR | |
| SCHEMBL8417863 | 0.86 | ALDH1A1 (0.39) | KMT2AMAPTALDH1A1TSHRNPSR1 | |
| SCHEMBL8357062 | 0.85 | ALDH1A1 (0.36) | KMT2AMAPTALDH1A1TSHRNPSR1 | |
| SCHEMBL8417450 | 0.85 | MAPT (0.36) | KMT2AMAPTALDH1A1TSHRNPSR1 | |
| SCHEMBL8421782 | 0.85 | ALDH1A1 (0.38) | MAPTALDH1A1TSHRNPSR1KDM4E | |
| SCHEMBL8417430 | 0.84 | MAPT (0.37) | MAPTALDH1A1TSHRNPSR1KDM4E | |
| SCHEMBL8417854 | 0.83 | ALDH1A1 (0.43) | KMT2AMAPTALDH1A1TSHRNPSR1 | |
| SCHEMBL3976312 | 0.75 | ALDH1A1 (0.42) | MAPTALDH1A1TSHRKDM4EDHODH | |
| SCHEMBL3978309 | 0.75 | FFAR1 (0.43) | MAPTALDH1A1TSHRNPSR1KDM4E | |
| SCHEMBL8419470 | 0.74 | MAPT (0.42) | MAPTALDH1A1NPSR1KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5962491-A | ANGIOTENSIN ANTAGONIST, HYPOTENSIVE AGENTS, CARDIOVASCULAR DISORDERS, STROKES | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1999-10-05 | — | — | US | disclosed |
| US-5705517-A | ANGIOTENSIN II ANTAGONISTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-01-06 | — | — | US | disclosed |
| US-5703110-A | HYPOTENSIVE AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-12-30 | — | — | US | disclosed |