SCHEMBL8417431

SCHEMBL8417431

COC(=O)CCCc1ccc(C(CCC(F)(F)C(F)(F)C(F)(F)F)NS(=O)(=O)c2ccc(F)cc2)cc1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EEF2K O00418 2/20 0.37
RAB9A P51151 1/20 0.37
FFAR1 O14842 1/20 0.37
FFAR4 Q5NUL3 1/20 0.37
SIGMAR1 Q99720 1/20 0.37
GFER P55789 1/20 0.36
ALDH1A1 P00352 4/20 0.36
CA12 O43570 1/20 0.36
CA2 P00918 1/20 0.36
CA7 P43166 1/20 0.36
CA9 Q16790 1/20 0.36
CA14 Q9ULX7 1/20 0.36
NPSR1 Q6W5P4 1/20 0.36
IDO1 P14902 1/20 0.36
ATM Q13315 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
EGFR P00533 1/20 0.35
ERBB2 P04626 1/20 0.35
POLB P06746 2/20 0.35
CYP1A2 P05177 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8419466 0.97 EEF2K (0.37) EEF2KRAB9AFFAR1FFAR4SIGMAR1
SCHEMBL8418072 0.97 SIGMAR1 (0.39) EEF2KRAB9AFFAR1FFAR4SIGMAR1
SCHEMBL8419600 0.95 EEF2K (0.36) EEF2KRAB9AFFAR1FFAR4SIGMAR1
SCHEMBL8419685 0.92 UTS2R (0.42) EEF2KALDH1A1NPSR1CYP1A2CYP2C19
SCHEMBL8417532 0.92 SIGMAR1 (0.40) EEF2KRAB9AFFAR1FFAR4SIGMAR1
SCHEMBL8419633 0.90 SIGMAR1 (0.39) EEF2KRAB9AFFAR1FFAR4SIGMAR1
SCHEMBL8418045 0.90 LMNA (0.43) EEF2KFFAR1FFAR4SIGMAR1GFER
SCHEMBL8418074 0.89 UTS2R (0.41) EEF2KALDH1A1NPSR1CYP1A2CYP2C19
SCHEMBL8417479 0.89 UTS2R (0.42) EEF2KALDH1A1NPSR1IDO1CYP1A2
SCHEMBL8417445 0.89 SIGMAR1 (0.40) EEF2KRAB9AFFAR1FFAR4SIGMAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0943606-A1 BENZENESULFONAMIDE DERIVATIVES AND DRUGS CONTAINING THE SAME HOKURIKU SEIYAKU CO., LTD. (JP) 1999-09-22 EP disclosed