Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | AKR1B10 | O60218 | 5/20 | 0.47 |
| ▸ | AKR1B1 | P15121 | 5/20 | 0.47 |
| ▸ | CA12 | O43570 | 2/20 | 0.47 |
| ▸ | CA1 | P00915 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | CA7 | P43166 | 2/20 | 0.47 |
| ▸ | CA9 | Q16790 | 2/20 | 0.47 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9820601 | 0.81 | ESR1 (0.46) | ALDH1A1MAPTKDM4EMEN1TP53 | |
| SCHEMBL15960946 | 0.78 | ESR1 (0.62) | ALDH1A1MAPTKDM4EMEN1TP53 | |
| SCHEMBL10021706 | 0.76 | CAPN1 (0.50) | ALDH1A1MAPTMEN1CYP1A2CYP2C9 | |
| SCHEMBL8417660 | 0.76 | AKR1B10 (0.58) | ALDH1A1MAPTKDM4EMEN1TP53 | |
| SCHEMBL8417663 | 0.76 | AKR1B10 (0.58) | ALDH1A1MAPTKDM4EMEN1TP53 | |
| SCHEMBL9820607 | 0.76 | TYR (0.53) | ALDH1A1MAPTKDM4EMEN1TP53 | |
| SCHEMBL27459372 | 0.76 | CA12 (0.43) | ALDH1A1MAPTKDM4EMEN1TP53 | |
| SCHEMBL18517696 | 0.75 | MAPT (0.50) | ALDH1A1MAPTKDM4EMEN1TP53 | |
| SCHEMBL547439 | 0.75 | MIF (0.64) | ALDH1A1MAPTAKR1B10AKR1B1CA12 | |
| SCHEMBL547437 | 0.75 | MIF (0.64) | ALDH1A1MAPTAKR1B10AKR1B1CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5919793-A | QUINUCLIDINE DERIVATIVES, SQUALENE SYNTHETASE INHIBITORS, ANTICHOLESTEROL AGENTS | ZENECA LIMITED (GB) | 1999-07-06 | — | — | US | disclosed |
| CN-1121718-A | Heterocyclic derivatives | ZENECA LTD (GB) | 1996-05-01 | — | — | CN | disclosed |
| EP-0696284-A1 | HETEROCYCLIC DERIVATIVES | ZENECA LIMITED (GB) | 1996-02-14 | — | — | EP | disclosed |
| WO-1994025459-A1 | HETEROCYCLIC DERIVATIVES | ZENECA LIMITED (GB) | 1994-11-10 | — | — | WO | disclosed |