Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 3/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.49 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | MAOA | P21397 | 1/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3686436 | 0.85 | FFAR1 (0.59) | MEN1KMT2ALMNAL3MBTL1FFAR1 | |
| SCHEMBL11023299 | 0.84 | ADRB2 (0.53) | MEN1KMT2AALDH1A1MAPTPOLB | |
| SCHEMBL8022636 | 0.84 | MEN1 (0.51) | MEN1KMT2AALDH1A1MAPTPOLB | |
| SCHEMBL8421939 | 0.84 | MEN1 (0.51) | MEN1KMT2AALDH1A1MAPTPOLB | |
| SCHEMBL11981916 | 0.84 | MEN1 (0.51) | MEN1KMT2AALDH1A1MAPTPOLB | |
| SCHEMBL10805062 | 0.84 | NDUFS8 (0.53) | MEN1KMT2AALDH1A1MAPTNPC1 | |
| SCHEMBL8024395 | 0.82 | CYP4F2 (0.59) | MEN1KMT2AALDH1A1MAPTPOLB | |
| SCHEMBL2097631 | 0.81 | ALDH1A1 (0.53) | MEN1KMT2AALDH1A1MAPTNPC1 | |
| SCHEMBL10799299 | 0.81 | MEN1 (0.49) | MEN1KMT2AALDH1A1MAPTNPC1 | |
| SCHEMBL2556045 | 0.80 | MEN1 (0.51) | MEN1KMT2AALDH1A1MAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5919793-A | QUINUCLIDINE DERIVATIVES, SQUALENE SYNTHETASE INHIBITORS, ANTICHOLESTEROL AGENTS | ZENECA LIMITED (GB) | 1999-07-06 | — | — | US | disclosed |
| CN-1121718-A | Heterocyclic derivatives | ZENECA LTD (GB) | 1996-05-01 | — | — | CN | disclosed |
| EP-0696284-A1 | HETEROCYCLIC DERIVATIVES | ZENECA LIMITED (GB) | 1996-02-14 | — | — | EP | disclosed |
| WO-1994025459-A1 | HETEROCYCLIC DERIVATIVES | ZENECA LIMITED (GB) | 1994-11-10 | — | — | WO | disclosed |
| US-4393079-A | ANTIINFLAMMATORY AROMATIC KETONES | BEECHAM GROUP LIMITED (GB) | 1983-07-12 | — | — | US | disclosed |
| US-4216232-A | Pharmaceutical compositions | BEECHAM GROUP LIMITED (GB) | 1980-08-05 | — | — | US | disclosed |