Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 2/20 | 0.39 |
| ▸ | MAOB | P27338 | 2/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21382605 | 0.92 | L3MBTL1 (0.42) | TAAR1HTR2AL3MBTL1KDM4EGLA | |
| SCHEMBL517859 | 0.89 | TAAR1 (0.50) | TAAR1HTR2AL3MBTL1KDM4EGLA | |
| SCHEMBL2515837 | 0.89 | TAAR1 (0.54) | TAAR1HTR2APOLBCTDSP1IDO1 | |
| SCHEMBL2172552 | 0.86 | TAAR1 (0.44) | TAAR1HTR2AL3MBTL1KDM4EGLA | |
| SCHEMBL18218371 | 0.85 | L3MBTL1 (0.46) | TAAR1HTR2AL3MBTL1KDM4EGLA | |
| SCHEMBL19792648 | 0.84 | RAD52 (0.39) | TAAR1L3MBTL1KDM4EGLAMAPT | |
| SCHEMBL26987687 | 0.83 | TAAR1 (0.50) | TAAR1HTR2AL3MBTL1KDM4EGLA | |
| SCHEMBL8447026 | 0.83 | KCNH2 (0.51) | TAAR1MAPTALDH1A1IDO1MEN1 | |
| SCHEMBL1680408 | 0.83 | TAAR1 (0.45) | TAAR1HTR2AL3MBTL1POLBCTDSP1 | |
| SCHEMBL15602862 | 0.83 | IDO1 (0.48) | L3MBTL1KDM4EGLAMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5919793-A | QUINUCLIDINE DERIVATIVES, SQUALENE SYNTHETASE INHIBITORS, ANTICHOLESTEROL AGENTS | ZENECA LIMITED (GB) | 1999-07-06 | — | — | US | disclosed |
| CN-1121718-A | Heterocyclic derivatives | ZENECA LTD (GB) | 1996-05-01 | — | — | CN | disclosed |
| EP-0696284-A1 | HETEROCYCLIC DERIVATIVES | ZENECA LIMITED (GB) | 1996-02-14 | — | — | EP | disclosed |
| WO-1994025459-A1 | HETEROCYCLIC DERIVATIVES | ZENECA LIMITED (GB) | 1994-11-10 | — | — | WO | disclosed |