SCHEMBL8417853

SCHEMBL8417853

CCc1ccc(Oc2ccc(N)cc2)c(C)c1

nearest known ligand 0.57

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.46
SMN1; SMN2 Q16637 3/20 0.46
NPC1 O15118 2/20 0.44
RAB9A P51151 2/20 0.44
TEAD4 Q15561 1/20 0.44
TDP1 Q9NUW8 3/20 0.43
MAPT P10636 2/20 0.43
POLB P06746 1/20 0.43
CARM1 Q86X55 3/20 0.42
PRMT6 Q96LA8 3/20 0.42
TSHR P16473 2/20 0.42
CYP3A4 P08684 1/20 0.42
CYP19A1 P11511 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30026989 0.90 SMN1; SMN2 (0.48) ALDH1A1SMN1; SMN2NPC1RAB9ATEAD4
SCHEMBL2512315 0.88 ALDH1A1 (0.47) ALDH1A1SMN1; SMN2TEAD4TDP1MAPT
SCHEMBL8415231 0.87 CYP19A1 (0.45) ALDH1A1SMN1; SMN2RAB9ATEAD4TDP1
SCHEMBL12806587 0.85 L3MBTL1 (0.46) ALDH1A1NPC1RAB9ATDP1MAPT
SCHEMBL8578378 0.84 SKP2 (0.55) ALDH1A1SMN1; SMN2CYP19A1
SCHEMBL9504922 0.83 TTR (0.46) SMN1; SMN2NPC1RAB9ACARM1PRMT6
SCHEMBL8582322 0.83 SMN1; SMN2 (0.43) ALDH1A1SMN1; SMN2NPC1RAB9ATEAD4
SCHEMBL13894652 0.83 CARM1 (0.53) ALDH1A1SMN1; SMN2MAPTCARM1PRMT6
SCHEMBL12310613 0.83 TTR (0.49)
SCHEMBL31457276 0.82 ALDH1A1 (0.55) ALDH1A1SMN1; SMN2NPC1RAB9ATEAD4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5914354-A POLYIMIDE PRECURSOR, TERTIARY AMINE, PHOTOPOLYMERIZATION INITIATOR, SENSITIZER; THICK FILMS SHIN-ETSU CHEMICAL CO., LTD. (JP) 1999-06-22 US disclosed
US-5744203-A POLYMER MIXTURES OF POLYURETHANES, POLYESTERS, POLYIMIDES, POLYCARBONATES AND POLYUREAS HOECHST AKTIENGESELLSCHAFT (DE) 1998-04-28 US disclosed
US-5670084-A Alignment layer material for liquid crystal display devices HOECHST AKTIENGESELLSCHAFT (DE) 1997-09-23 US disclosed