SCHEMBL8578378

SCHEMBL8578378

CCCCc1ccc(Oc2ccc(N)cc2)c(C)c1

nearest known ligand 0.67

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
SKP2 Q13309 1/20 0.55
CYP19A1 P11511 1/20 0.43
SMN1; SMN2 Q16637 2/20 0.43
GLA P06280 1/20 0.43
ALDH1A1 P00352 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8415231 0.91 CYP19A1 (0.45) SKP2CYP19A1SMN1; SMN2ALDH1A1
SCHEMBL10733889 0.85 SKP2 (0.47) SKP2SMN1; SMN2GLA
SCHEMBL9502798 0.85 SKP2 (0.47) SKP2
SCHEMBL8417853 0.84 ALDH1A1 (0.46) CYP19A1SMN1; SMN2ALDH1A1
SCHEMBL2946734 0.84 SKP2 (0.43) SKP2CYP19A1SMN1; SMN2GLA
SCHEMBL2512315 0.83 ALDH1A1 (0.47) CYP19A1SMN1; SMN2ALDH1A1
SCHEMBL8579599 0.82 SKP2 (0.50) SKP2CYP19A1SMN1; SMN2ALDH1A1
SCHEMBL9297209 0.82 ALDH1A1 (0.46) CYP19A1SMN1; SMN2ALDH1A1
SCHEMBL8580932 0.81 CYP19A1 (0.42) SKP2CYP19A1SMN1; SMN2GLAALDH1A1
SCHEMBL6558445 0.81 ALDH1A1 (0.54) SKP2CYP19A1SMN1; SMN2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5744203-A POLYMER MIXTURES OF POLYURETHANES, POLYESTERS, POLYIMIDES, POLYCARBONATES AND POLYUREAS HOECHST AKTIENGESELLSCHAFT (DE) 1998-04-28 US disclosed
US-5670084-A Alignment layer material for liquid crystal display devices HOECHST AKTIENGESELLSCHAFT (DE) 1997-09-23 US disclosed
US-5510425-A AROMATIC POLYIMIDE-EPOXY COPOLYMER MODIFIED BY BISMALEIMIDE COMPOUND; FLEXIBILITY, PEELING STRENGTH; COLDSETTING RESINS, ADHESIVES HITACHI CHEMICAL COMPANY, LTD. (JP) 1996-04-23 US disclosed