Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 3/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 6/20 | 0.41 |
| ▸ | TRAP1 | Q12931 | 4/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.40 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.39 |
| ▸ | ADA | P00813 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.34 |
| ▸ | PDE9A | O76083 | 5/20 | 0.34 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | MTOR | P42345 | 1/20 | 0.32 |
| ▸ | RICTOR | Q6R327 | 1/20 | 0.32 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.32 |
| ▸ | MAPKAP1 | Q9BPZ7 | 1/20 | 0.32 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31403622 | 0.89 | ADORA2A (0.46) | ADORA2AADORA1HSP90AA1TRAP1HSP90AB1 | |
| SCHEMBL8418288 | 0.80 | XDH (0.35) | KDM4EPDE1CPDE9A | |
| SCHEMBL17889388 | 0.76 | PDE2A (0.47) | ADORA2AADORA1HSP90AA1TRAP1HSP90AB1 | |
| SCHEMBL28688151 | 0.73 | HSP90AA1 (0.48) | ADORA2AADORA1HSP90AA1TRAP1HSP90AB1 | |
| SCHEMBL2357706 | 0.71 | KDM4E (0.43) | KDM4EKMT2APDE1CPDE9A | |
| SCHEMBL21459294 | 0.71 | CDK1 (0.44) | KDM4EKMT2APDE1CPDE9ASLC2A1 | |
| SCHEMBL29399563 | 0.71 | CDK1 (0.44) | KDM4EKMT2APDE1CPDE9ASLC2A1 | |
| SCHEMBL23918240 | 0.70 | KDM4E (0.42) | KDM4EKMT2APDE1CPDE9A | |
| SCHEMBL31051051 | 0.70 | KDM4E (0.42) | KDM4EKMT2APDE1CPDE9A | |
| SCHEMBL8221333 | 0.69 | HSP90AA1 (0.52) | ADORA2AADORA1HSP90AA1TRAP1HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7465740-B2 | 2-heteroaryl-pyrazolo-[4,3-e]-1,2,4-triazolo-[1,5-c]-pyrimidine adenosine A2a receptor antagonists | SCHERING CORPORATION (US) | 2008-12-16 | — | — | US | disclosed |
| US-20070066620-A1 | 2-Heteroaryl-pyrazolo-[4,3-e]-1,2,4-triazolo-[1,5-c]-pyrimidine adenosine A2a receptor antagonists | MERCK SHARP & DOHME LLC | 2007-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070066620-A1 | 2-Heteroaryl-pyrazolo-[4,3-e]-1,2,4-triazolo-[1,5-c]-pyrimidine adenosine A2a receptor antagonists | ADORA2A, ADORA3, ADORA1 | ADORA2A 1/4885ADORA1 3/4885HSP90AA1 3512/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.