Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 5/20 | 0.39 |
| ▸ | PPARD | Q03181 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8418577 | 0.90 | PPARA (0.41) | PPARAPPARDMAPTTHRBGABRA1 | |
| SCHEMBL8418495 | 0.86 | PPARA (0.37) | PPARAPPARDGABRA1GABRB2KDM4E | |
| SCHEMBL8419729 | 0.84 | PPARA (0.39) | PPARAPPARDMAPTTHRBKDM4E | |
| SCHEMBL27546795 | 0.81 | ELANE (0.42) | MAPTTHRBKDM4EALDH1A1L3MBTL1 | |
| SCHEMBL8419659 | 0.81 | KDM4E (0.39) | PPARAPPARDMAPTTHRBGABRA1 | |
| SCHEMBL8421612 | 0.80 | PPARA (0.44) | PPARAPPARD | |
| SCHEMBL9263590 | 0.80 | ELANE (0.36) | PPARAPPARDMAPTGABRA1GABRB2 | |
| SCHEMBL8418587 | 0.79 | GABRA1 (0.43) | MAPTGABRA1GABRB2KDM4EALDH1A1 | |
| SCHEMBL8422008 | 0.79 | PPARA (0.49) | PPARAPPARD | |
| SCHEMBL8419836 | 0.77 | ALOX5 (0.41) | PPARAPPARDMAPTGABRA1GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5919793-A | QUINUCLIDINE DERIVATIVES, SQUALENE SYNTHETASE INHIBITORS, ANTICHOLESTEROL AGENTS | ZENECA LIMITED (GB) | 1999-07-06 | — | — | US | disclosed |
| EP-0696284-A1 | HETEROCYCLIC DERIVATIVES | ZENECA LIMITED (GB) | 1996-02-14 | — | — | EP | disclosed |
| WO-1994025459-A1 | HETEROCYCLIC DERIVATIVES | ZENECA LIMITED (GB) | 1994-11-10 | — | — | WO | disclosed |