Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 8/20 | 0.52 |
| ▸ | LTB4R2 | Q9NPC1 | 8/20 | 0.52 |
| ▸ | MAOB | P27338 | 2/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | FABP4 | P15090 | 1/20 | 0.39 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | SLC26A4 | O43511 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PPARD | Q03181 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.38 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8422311 | 0.88 | LTB4R (0.52) | LTB4RLTB4R2MAOBKMT2AMEN1 | |
| SCHEMBL8420359 | 0.81 | LTB4R (0.52) | LTB4RLTB4R2FFAR1PPARGPPARD | |
| SCHEMBL7988629 | 0.80 | LTB4R (0.73) | LTB4RLTB4R2MAOBMAOANR4A2 | |
| SCHEMBL7988633 | 0.80 | LTB4R (0.73) | LTB4RLTB4R2MAOBMAOANR4A2 | |
| SCHEMBL7988639 | 0.80 | LTB4R (0.73) | LTB4RLTB4R2MAOBMAOANR4A2 | |
| SCHEMBL8418438 | 0.77 | LTB4R (0.54) | LTB4RLTB4R2RAB9AKMT2AMAPT | |
| SCHEMBL8571699 | 0.73 | LTB4R (0.52) | LTB4RLTB4R2RAB9AKMT2AMAPT | |
| SCHEMBL8420169 | 0.73 | LTB4R (0.52) | LTB4RLTB4R2RAB9ANPC1KMT2A | |
| SCHEMBL8569978 | 0.73 | LTB4R (0.52) | LTB4RLTB4R2RAB9ANPC1KMT2A | |
| SCHEMBL8564500 | 0.73 | LTB4R (0.65) | LTB4RLTB4R2RAB9AKMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0942903-A1 | ARYL-SUBSTITUTED ACRYLAMIDES WITH LEUKOTRIENE B4 (LTB-4) RECEPTOR ANTAGONIST ACTIVITY | Novartis AG (CH) | 1999-09-22 | — | — | EP | disclosed |
| WO-1998013347-A1 | ARYL-SUBSTITUTED ACRYLAMIDES WITH LEUKOTRIENE B4 (LTB-4) RECEPTOR ANTAGONIST ACTIVITY | NOVARTIS AG (CH) | 1998-04-02 | — | — | WO | disclosed |