SCHEMBL8418977

SCHEMBL8418977

CC(c1cc(C(C)N(C)C)c(C(C)N(C)C)cc1O)N(C)C

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 3/20 0.37
MAPT P10636 3/20 0.37
KMT2A Q03164 3/20 0.37
CYP2C9 P11712 1/20 0.37
LMNA P02545 3/20 0.35
TRPA1 O75762 1/20 0.35
CHRM1 P11229 1/20 0.35
SLC6A2 P23975 1/20 0.35
ADRA1A P35348 1/20 0.35
HTR2B P41595 1/20 0.35
CRHBP P24387 1/20 0.35
CRHR2 Q13324 1/20 0.35
ACHE P22303 4/20 0.34
GSR P00390 1/20 0.32
GABRA1 P14867 2/20 0.31
GABRB2 P47870 2/20 0.31
BCHE P06276 2/20 0.31
GPR55 Q9Y2T6 1/20 0.31
CA1 P00915 1/20 0.31
CA2 P00918 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10949863 0.74 LMNA (0.48) MEN1MAPTKMT2ACYP2C9LMNA
SCHEMBL3814477 0.74 MAPT (0.41) MEN1MAPTKMT2ACYP2C9LMNA
SCHEMBL29964165 0.73 ALOX15 (0.43) MEN1MAPTKMT2ACYP2C9LMNA
SCHEMBL5681794 0.73 PDE10A (0.45) MEN1MAPTKMT2ACYP2C9LMNA
SCHEMBL623519 0.70 MEN1 (0.40) MEN1MAPTKMT2ACYP2C9LMNA
SCHEMBL36796 0.70 GABRA1 (0.60) MEN1MAPTKMT2ACYP2C9LMNA
SCHEMBL11144707 0.69 LMNA (0.54) LMNATRPA1CHRM1SLC6A2ADRA1A
SCHEMBL67859 0.68 LMNA (0.58) LMNATRPA1CHRM1SLC6A2ADRA1A
SCHEMBL2367079 0.67 MEN1 (0.38) MEN1MAPTKMT2ACYP2C9LMNA
SCHEMBL11278964 0.66 CYP2C19 (0.44) MEN1MAPTKMT2ACYP2C9LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0487291-B1 Photocurable silicon composition, and method of making same LOCTITE CORP (US) 1999-09-29 EP disclosed
US-5348986-A Polysiloxanes capped with mixture of curable groups, gels, acrylated polymers LOCTITE CORPORATION (US) 1994-09-20 US disclosed
US-5212211-A Adhesives, coatings LOCTITE CORPORATION (US) 1993-05-18 US disclosed
EP-0487291-A2 Photocurable silicon composition, and method of making same LOCTITE CORPORATION (US) 1992-05-27 EP disclosed
EP-0101587-B1 POSITIVE PROCESS FOR OBTAINING RELIEF OR RESIST PATTERNS BASF Aktiengesellschaft (DE) 1987-01-21 EP disclosed
EP-0101587-A2 Positive process for obtaining relief or resist patterns BASF Aktiengesellschaft (DE) 1984-02-29 EP disclosed