Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD1 | P21728 | 8/20 | 0.48 |
| ▸ | DRD5 | P21918 | 7/20 | 0.48 |
| ▸ | DRD2 | P14416 | 7/20 | 0.48 |
| ▸ | DRD3 | P35462 | 7/20 | 0.48 |
| ▸ | DRD4 | P21917 | 5/20 | 0.48 |
| ▸ | BCL2 | P10415 | 1/20 | 0.46 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL446529 | 0.89 | DRD1 (0.50) | DRD1DRD5DRD2DRD3DRD4 | |
| SCHEMBL444147 | 0.82 | DRD2 (0.47) | DRD1DRD5DRD2DRD3DRD4 | |
| SCHEMBL586334 | 0.81 | DRD2 (0.47) | DRD1DRD5DRD2DRD3DRD4 | |
| SCHEMBL1506557 | 0.79 | DRD1 (0.62) | DRD1DRD5DRD2DRD3DRD4 | |
| SCHEMBL31028084 | 0.79 | DRD1 (0.62) | DRD1DRD5DRD2DRD3DRD4 | |
| SCHEMBL30299229 | 0.79 | DRD1 (0.62) | DRD1DRD5DRD2DRD3DRD4 | |
| SCHEMBL577378 | 0.79 | DRD1 (0.62) | DRD1DRD5DRD2DRD3DRD4 | |
| SCHEMBL1550649 | 0.78 | DRD1 (0.53) | DRD1DRD5DRD2DRD3DRD4 | |
| SCHEMBL4133301 | 0.77 | DRD1 (0.60) | DRD1DRD5DRD2DRD3DRD4 | |
| SCHEMBL30888625 | 0.77 | DRD1 (0.60) | DRD1DRD5DRD2DRD3DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6004977-A | ANTIDEPRESSANTS, COGNITION ACTIVATORS, AND ALZHEIMER'S DISEASE TREATMENT | HOECHST MARION ROUSSEL, INC. (US) | 1999-12-21 | — | — | US | disclosed |