Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRPF1 | P55201 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | HTT | P42858 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | FDPS | P14324 | 3/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.33 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4366901 | 0.85 | ALDH1A1 (0.44) | KDM4EHPGDALDH1A1TSHRMAPT | |
| SCHEMBL8419945 | 0.84 | CA12 (0.33) | KDM4EHTTKMT2AALDH1A1MAPT | |
| SCHEMBL13392322 | 0.84 | ALDH1A1 (0.45) | KDM4EHTTKMT2AHPGDALDH1A1 | |
| SCHEMBL8419947 | 0.82 | TSHR (0.53) | KDM4EHTTKMT2AHPGDALDH1A1 | |
| SCHEMBL13392323 | 0.79 | ALDH1A1 (0.45) | KDM4EHTTKMT2AHPGDALDH1A1 | |
| SCHEMBL25015012 | 0.79 | MAPT (0.48) | KDM4EHTTKMT2AHPGDALDH1A1 | |
| SCHEMBL23882961 | 0.77 | FDPS (0.41) | KDM4EKMT2AALDH1A1TSHRFDPS | |
| SCHEMBL24962415 | 0.74 | MAPT (0.49) | KDM4EHTTKMT2AHPGDALDH1A1 | |
| SCHEMBL4667829 | 0.72 | MAPT (0.45) | KDM4EHTTKMT2AHPGDALDH1A1 | |
| SCHEMBL257677 | 0.72 | TDP1 (0.46) | KDM4EHTTKMT2AHPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5919793-A | QUINUCLIDINE DERIVATIVES, SQUALENE SYNTHETASE INHIBITORS, ANTICHOLESTEROL AGENTS | ZENECA LIMITED (GB) | 1999-07-06 | — | — | US | disclosed |
| CN-1121718-A | Heterocyclic derivatives | ZENECA LTD (GB) | 1996-05-01 | — | — | CN | disclosed |
| EP-0696284-A1 | HETEROCYCLIC DERIVATIVES | ZENECA LIMITED (GB) | 1996-02-14 | — | — | EP | disclosed |
| WO-1994025459-A1 | HETEROCYCLIC DERIVATIVES | ZENECA LIMITED (GB) | 1994-11-10 | — | — | WO | disclosed |