Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.37 |
| ▸ | FDPS | P14324 | 2/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13392322 | 0.90 | ALDH1A1 (0.45) | MAPTKMT2AKDM4EHTTHPGD | |
| SCHEMBL23882961 | 0.88 | FDPS (0.41) | TSHRMAPTPOLBL3MBTL1KMT2A | |
| SCHEMBL13392323 | 0.85 | ALDH1A1 (0.45) | TSHRKMT2AKDM4EHTTGAA | |
| SCHEMBL25015012 | 0.84 | MAPT (0.48) | MAPTL3MBTL1KMT2AKDM4EHTT | |
| SCHEMBL8419951 | 0.82 | BRPF1 (0.40) | TSHRMAPTKMT2AKDM4EHTT | |
| SCHEMBL4359950 | 0.82 | TSHR (0.53) | TSHRMAPTPOLBL3MBTL1KMT2A | |
| SCHEMBL24962427 | 0.81 | ALDH1A1 (0.49) | TSHRMAPTPOLBL3MBTL1KMT2A | |
| SCHEMBL6491358 | 0.81 | TSHR (0.54) | TSHRMAPTPOLBL3MBTL1KMT2A | |
| SCHEMBL15430834 | 0.80 | TSHR (0.50) | TSHRMAPTPOLBL3MBTL1KDM4E | |
| SCHEMBL24962709 | 0.79 | TSHR (0.45) | TSHRMAPTKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5919793-A | QUINUCLIDINE DERIVATIVES, SQUALENE SYNTHETASE INHIBITORS, ANTICHOLESTEROL AGENTS | ZENECA LIMITED (GB) | 1999-07-06 | — | — | US | disclosed |
| CN-1121718-A | Heterocyclic derivatives | ZENECA LTD (GB) | 1996-05-01 | — | — | CN | disclosed |
| EP-0696284-A1 | HETEROCYCLIC DERIVATIVES | ZENECA LIMITED (GB) | 1996-02-14 | — | — | EP | disclosed |
| WO-1994025459-A1 | HETEROCYCLIC DERIVATIVES | ZENECA LIMITED (GB) | 1994-11-10 | — | — | WO | disclosed |